Gene therapy for disease X: from the bench to clinic

8 março 2019, 15:00 • Gabriel Monteiro

Gene therapy for disease X: from the bench to clinic. Students presentations

Hemophilia type B (83764, 91924, 83835, 83791, 83852)

Cystic fibrosis (83742, 83808, 83757, 83848, 83857)

Hemophilia (93956, 93923, 83776, 80836, 93970)

Sickle cell disease (92042, 94418, 94433, 94575, 94556)

Sickle cell Anemia (94022, 93957, 81037)

Hands-on project: non-viral vectors

6 março 2019, 16:30 • Gabriel Monteiro

Hands-on project: non-viral vectors. (project implemented and performed by students)

Gene therapy tools

1 março 2019, 15:00 • Gabriel Monteiro

- Design and selection of xenonucleic acids (PNAs, LNAs, morpholinos, aptamers) -DNA vaccines

Gene therapy tools

27 fevereiro 2019, 16:30 • Gabriel Monteiro

- Modification of gene transcription and/or translation by gene knockout, knockin and knockdown using autologous and heterologous genes. Target diseases and examples of clinical trials.

Gene and cell therapies tools

22 fevereiro 2019, 15:00 • Gabriel Monteiro

- Gene and cell therapy tools: viruses, plasmids, XNAs, RNAi and gene editing systems.

- Barriers to biopharmaceuticals delivery. Bioavailability and Clearance. Optimization of gene delivery systems by sequence modifications, regulatory elements and shielding (e.g. lipoplexes, polyplexes).