Sumários

Manufacturing of non-viral vectors

5 Abril 2019, 15:00 Duarte Miguel De França Teixeira dos Prazeres

Manufacturing of non-viral vectors. Overview of test items, specifications and analytics. Upstream and Downstream processing. Cell banking. Cell culture. Downstream processing challenges. In-class group exercise on downstream processing of plasmids.


Manufacturing of non-viral vectors

15 Março 2019, 15:00 Duarte Miguel De França Teixeira dos Prazeres

Manufacturing of non-viral vectors. Product and process development. Regulation framework and the quality tripod (GLPs, GMPs and GCPs). INDs and BLAs. Clinical trials. Quizz on clicnial trials an regulation. Overview of plasmid manufacturing. Main impurities and key properties: genomic DNA, RNA, LPS and RNA. In-class group exercise on test items, specifications and analytics.


Gene therapy by the numbers

13 Março 2019, 16:30 Duarte Miguel De França Teixeira dos Prazeres

Gene therapy by the numbers. A quantitative approach to cell biology.  Key numbers in Biology: size, length scale, concentration, diffusion. Basic calculations and estimates.