Sumários
Stem cell-based Therapies
24 abril 2019, 16:30 • Cláudia Lobato da Silva
Stem cell-based Therapies: Examples. Autologous versus Allogeneic therapies
Invited Seminar "Virus Biology"
12 abril 2019, 15:00 • Cláudia Lobato da Silva
Invited seminar entitled "Virus Biology" given by Dr. Miguel Fevereiro from INIAV.
Viral vectors
10 abril 2019, 16:30 • Duarte Miguel de França Teixeira dos Prazeres
Why viral vectors? Safety issues: immunogenicity and genotoxicity. Viral vector-based gene transfer. Main vectors used in gene transfer: adenovirus, retrovirus, adeno associated virus and lentivirus. From virus to viral vectors. Vector design and engineering. Challenges in viral vector-based gene transfer: i) evading pre-existent immunity, ii) transductioin efficiency, iii) targeted delivery and iv) genomic maintenance. Viral vector manufacturing.
Manufacturing of non-viral vectors
5 abril 2019, 15:00 • Duarte Miguel de França Teixeira dos Prazeres
Manufacturing of non-viral vectors. Overview of test items, specifications and analytics. Upstream and Downstream processing. Cell banking. Cell culture. Downstream processing challenges. In-class group exercise on downstream processing of plasmids.
Invited seminar, Manufacturing of minicircles and transfection of MSC
29 março 2019, 15:00 • Gabriel Monteiro
Case studies: manufacturing of minicircles and transfection of MSC, Joana Serra, iBB