Sumários
Multidrug resistance in eukaryotes
28 outubro 2019, 09:00 • Miguel Nobre Parreira Cacho Teixeira
Definition and mechanisms of multidrug resistance. The paradigmatic case of the study of the role of the human p-glycoprotein in the resistance to chemotherapy. Biochemical and structural analysis of the function of the ATP-Binding Cassette (ABC) superfamily transporters.
Transcriptional regulatory networks in eukaryotes
23 outubro 2019, 09:00 • Miguel Nobre Parreira Cacho Teixeira
The complexity of transcription factor (TF) interplay and cross-talk in the control of gene and genomic expression. The case-study of the Saccharomyces ceresiviae PDR network, highlighting the action of specific TFs individually, as homo- and heterodimers and as co-existing partners in the promoter region of their targets.
Regulation of gene expression in eukaryotes
21 outubro 2019, 09:00 • Miguel Nobre Parreira Cacho Teixeira
Influence of chromatin structure in gene transcription. Conservation of transcriptional regulation, transcription factor-DNA binding sites and nucleosome occupancy in eukaryotes.
Regulation of gene expression in eukaryotes
16 outubro 2019, 09:00 • Miguel Nobre Parreira Cacho Teixeira
General aspects of the process of transcription in eukaryotes. Activity of general and specific transcription factors. Methods for the characterization of transcription factor target genes and target DNA sequences. Introduction to the concept of transcription factories.
Microbial Mechanisms of Pathogenicity_II
14 outubro 2019, 09:00 • Arsénio do Carmo Sales Mendes Fialho
The Movement of Microbes into Hosts: Adherence. Avoidance of host defense mechanisms. Bacterial toxin mechanisms - alternative uses of bacterial toxins. Strategies of intracellular pathogens.