Regulation of gene expression in eukaryotes

21 outubro 2015, 09:00 • Miguel Nobre Parreira Cacho Teixeira

Introduction to the concept of transcription factories. Influence of chromatin structure in gene transcription. Conservation of transcriptional regulation, transcription factor-DNA binding sites and nucleosome occupancy in eukaryotes.

Immunity to bacterial infections

19 outubro 2015, 08:30 • Isabel Sá-Correia

Topics
•General terms about immunity
•Innate immune response
•Adaptive immune response
•The mechanisms of anti-bacterial infection
•Mechanisms of immune evasion
The class was given, at my request, by an invited colleague (Prof Paula Videira, FCT/UNL and CEDOC)

Regulation of gene expression in eukaryotes

14 outubro 2015, 09:00 • Miguel Nobre Parreira Cacho Teixeira

General aspects of the process of transcription in eukaryotes. Activity of general and specific transcription factors. Methods for the characterization of transcription factor target genes and target DNA sequences. 

Microbial Mechanisms of Pathogenicity_II/Microbial-based therapy of cancer

12 outubro 2015, 08:30 • Arsénio do Carmo Sales Mendes Fialho

Microbial Mechanisms of Pathogenicity - Bacterial toxin mechanisms - alternative uses of bacterial toxins. Strategies of intracellular pathogens.

Microbial-based therapy of cancer - Live bacteria and their products as new classes of multifunctional anticancer drugs

Beneficial bacteria - plant interactions: nitrogen fixation.

7 outubro 2015, 09:00 • Jorge Humberto Gomes Leitão

Nitrogen sources and availability to living organisms. Biological fixation of nitrogen. Initial steps in bacteria-plant interactions: production of flavenoids by plants and Nod factors by bacteria. Chemical structures of flavenoids and Nod factors. Bacteria and host cell events following initial recognition: formation of the infection thread, initial developments of a primordial nodule, maturation of the nodule and fixation of nitrogen by endosymbiotic bacteriods. Dinitrogenase and dinitrogenase reductase enzymes inlvoded in the conversion of dinitrogen into ammonia. Main biochemical pathawys occurring in a mature bacteriod fixing nitrogen.