Sumários
Stress response in eukaryotes
9 novembro 2015, 08:30 • Miguel Nobre Parreira Cacho Teixeira
The general stress response. Methods to detect oxidative stress and oxidative stress responsive mechanisms. Osmotic stress and Heat shock response. Autophagy.
Glucose transport and regulation in eukaryotes. Yeast as a model organism.
4 novembro 2015, 09:00 • Isabel Sá-Correia
Sugar transporters in yeasts:
specificity and variety. The hexose transporters and glucose sensors in Saccharomyces
cerevisiae: biochemical properties and general aspects of their evolution. Glucose
signaling in S. cerevisiae.
A aula foi lecionada por convite pela Doutora Margarida Palma, investigadora postdoc do Grupo de CiênciasBiológicas do iBB/IST.
Multidrug resistance in eukaryotes (cont.)
2 novembro 2015, 08:30 • Miguel Nobre Parreira Cacho Teixeira
Role of new transporters of the Major Facilitator Superfamily (MFS) that confer multidrug resistance: from S. cerevisiae to fungal pathogens. Development and application of chemosensitizers as co-adjuvants in the administration of anticancer and antifungal agents.
Multidrug resistance in eukaryotes
28 outubro 2015, 09:00 • Miguel Nobre Parreira Cacho Teixeira
Definition and mechanisms of multidrug resistance. The paradigmatic case of the study of the role of the human p-glycoprotein in the resistance to chemotherapy. Biochemical and structural analysis of the function of the ATP-Binding Cassette (ABC) superfamily transporters.
Transcriptional regulatory networks in eukaryotes
26 outubro 2015, 08:30 • Miguel Nobre Parreira Cacho Teixeira
The complexity of transcription factor (TF) interplay and cross-talk in the control of gene and genomic expression. The case-study of the Saccharomyces ceresiviae PDR network, highlighting the action of specific TFs individually, as homo- and heterodimers and as co-existing partners in the promoter region of their targets.