Transcriptional regulatory networks in eukaryotes

30 outubro 2012, 08:30 • Miguel Nobre Parreira Cacho Teixeira

Conservation of transcriptional regulation, transcription factor-DNA binding sites and nucleosome occupancy in eukaryotes.

The complexity of transcription factor (TF) interplay and cross-talk in the control of gene and genomic expression. The case-study of the Saccharomyces ceresiviae PDR network, highlighting the action of specific TFs individually, as homo- and heterodimers and as co-existing partners in the promoter region of their targets. Mechanisms of TF activation.

Regulation of gene expression in eukaryotes

26 outubro 2012, 14:00 • Miguel Nobre Parreira Cacho Teixeira

General aspects of the process of transcription in eukaryotes: introduction to the concept of transcription factories. Activity of general and specific transcription factors in the transcription process. Influence of chromatin structure in gene transcription.

Immunity to bacterial infections

23 outubro 2012, 08:30 • Isabel Sá-Correia

 Summary

General overview of the consequences of bacterial infection. Major differences between the Innate and Adaptive Immune Response. Elements of Innate Immune Response. Monocytes, macrophages, dendritic cells, neutrophils, eosinophils and basophils and cells of the innate immune response. The receptors for antigens Innate Immune response: location, function and pattern recognition. Definition of the acute phase response, and acute phase proteins. The chemokines and other molecules involved in cell adhesion and migration. The phenomenon of integrated cell migration in inflammation. The complement cascade activation pathways and consequences of activation. The phases of the innate immune response against microorganisms location of intra-and extra-cellular. Evasion mechanisms of different microorganisms.

A aula foi lecionada pela Doutora Paula Videira, Escola de Ciências Médicas, UNL e CEDOC

Microbial symbiosis

19 outubro 2012, 14:00 • Leonilde Morais Moreira

Importance and diversity of nitrogen fixation microorganisms. Steps involved in symbiotic development and the nitrogenase complex.

Microbial symbiosis

16 outubro 2012, 08:30 • Leonilde Morais Moreira

Arbuscular mycorrhiza diversity: symbiotic signaling and functioning.