Sumários
Microbial-based therapy of cancer
12 outubro 2012, 14:00 • Arsénio do Carmo Sales Mendes Fialho
Microbial-based therapy of cancer. Live bacteria and their products as new classes of multifunctional anticancer drugs
Microbial Mechanisms of Pathogenicity
9 outubro 2012, 08:30 • Arsénio do Carmo Sales Mendes Fialho
Important concepts in microbial pathogenesis:
Abundance / diversity / distribution of bacteria in nature.Pathogenesis / virulence factors, type of pathogens . Mechanisms of Pathogenicity . The Movement of Microbes into Hosts: Adherence. Avoidance of host defense mechanisms. Bacterial toxin mechanisms - alternative uses of bacterial toxins. Strategies of intracellular pathogens.
Signalling environmental stress through two-component systems.
2 outubro 2012, 08:30 • Nuno Gonçalo Pereira Mira
Structure/Function of histidine kinases (HKs) and response regulators (RRs).
Distribution of HKs and RRs throughout bacterial genus.
Role of HK/RRs in response to osmotic stress (EnvZ/OmpR system), nutrient limitation, changes in O2 availability (the Arc and FNR systems) and chemotaxis (the CheA/CheB/CheY system).
Stress responses in prokaryotes
28 setembro 2012, 14:00 • Nuno Gonçalo Pereira Mira
General stress response in the Gram negative model bacteria E. coli: important role of sigmaS.
Molecular mechanims of sigmaS regulation under stress.
Conservation of a sigmaS-dependet system in other Gram negative bacteria.
Link between the activity of stress-responsive sigma factors and virulence/pathogenesis.
Introduction to signalling pathways mediated by two component-systems.
Stress responses in prokaryotes
25 setembro 2012, 08:30 • Nuno Gonçalo Pereira Mira
Role of the alarmone ppGpp in regulation of the activity of alternative sigma factors under stress.
General stress response in the Gram positive model bacteria B. subtillis: the crucial role of sigmaB.
Molecular mechanisms of sigmaB regulation: involvement of the stressessome.
Conservation of the sigmaB-dependent system in other Gram positive bacteria.