Sumários
Introduction to Systems Biology
10 maio 2018, 10:00 • Miguel Nobre Parreira Cacho Teixeira
Introduction to Systems Biology. Definition and goals of this new discipline. Mathematical modeling of biochemical and regulatory pathways: general concepts, constraints and assets. Genomic Scale Models. Sctoichiometric matrix. Fluxome analysis.
Metabolic pathway modeling
9 maio 2018, 12:30 • Miguel Nobre Parreira Cacho Teixeira
Metabolic pathway modeling using the COPASI software. Mathematical description of biochemical pathways. Simulation of pathway behavior upon changes in enzyme kinetic parameters and upon changes in substrate concentrations.
Metabolic pathway modeling
8 maio 2018, 15:30 • Miguel Nobre Parreira Cacho Teixeira
Metabolic pathway modeling using the COPASI software. Mathematical description of biochemical pathways. Simulation of pathway behavior upon changes in enzyme kinetic parameters and upon changes in substrate concentrations.
Functional Genomics (cont.)
8 maio 2018, 09:00 • Miguel Nobre Parreira Cacho Teixeira
Omics approaches for the study of protein-protein (genome-wide yeast two-hybrid system; protein chips), protein-DNA (ChIP-on-chip and ChIP-seq) and protein-ligand (protein chips) interactions.
Metabolomics data analysis
4 maio 2018, 13:30 • Miguel Nobre Parreira Cacho Teixeira
Metabolomics data analysis using the online tool MetaboAnalyst: statistical (Correlation analysis, PCA, PLS-DA and clustering) and pathway enrichment analysis. Biological interpretation of the data.