Research Projects


International Projects

 

YEASTPEC - Engineering of the yeast Saccharomyces cerevisiae for bioconversion of pectin-containing agro-industrial side-streams

ERA-NET Industrial Biotechnology

Principal Investigator of the IST team: Isabel Sá-Correia

Contract: ERA-IB-16-013

Start date: 1/1/2017

Duration: 36 months


TTRAFFIC – Toxicity and Transport for Fungal Production of Industrial Compounds

ERA-NET Industrial Biotechnology

Principal Investigator of the IST team: Nuno Mira

Contract: ERA-IB-2-6/0003/2014

Start date: 1/4/2016

Duration: 36 months


Towards the development of sustainable bioprocesses for microbial production of carboxylic acids using renewable raw materials

Principal Investigator of the IST team: Nuno Mira

Contract: NFS interaction Grant, Fundação Luso-Americana para o Desenvolvimento

Start date: July 2014

Duration: 18 months


LEVITA - Towards microbial sustainable production of itaconic and levulinic acids

Principal Investigator of the IST team: Nuno Mira

Contract: EraSynBio Twinning program

Start date: April 2014

Duration: 6 months


Microbial cell surface determinants of virulence as targets for new therapeutics in Cystic fibrosis

COST Action

Principal Investigator of the IST team: Isabel Sá-Correia

Contract: COST Action BM1003

Start date: March 2011

Duration: 36 months

 

INTACT - Integral engineering of acetic acid tolerance in yeast

ERA-NET Industrial Biotechnology

Principal Investigator of the IST team: Isabel Sá-Correia

Contract: ERA-IB/0002/2010

Start date: March 2011

Duration: 36 months

 

ADHRES - Signature Project: Expression profiling of adhesive (ADH) and resistance (RES) genes in biofilm lifestyle in P. aeruginosa, P. putida and B. cenocepacia
ERA-NET PathoGenomics

Principal Investigator of the IST team: Isabel Sá-Correia

Contract: ERA-PTG/SAU/0001/2008

Start date: February 2009

Duration: 36 months

 

Insights into the mechanisms underlying the acquisition of antimicrobial resistance during chronic lung infection and the pathogenicity of Burkholderia cenocepacia

Funded by Cystic Fibrosis Foundation Therapeutics, a nonprofit affiliate to the Cystic Fibrosis Foundation - Burkholderia array project BA-009-A

Principal Investigator of the IST team: Isabel Sá-Correia

Start date: September 2008

Duration: 6 months

 

Strategies to accelerate the productive biodegradation of several herbicides under environmental stress conditions

Programme: Quality of Life and Management of Living Resources/ key action: The "Cell factory" (Fifth Framework Programme)

Principal Investigator of the IST team: Isabel Sá-Correia

Contract: QLK3-CT-1999-00041

Start date: January 2000

Duration: 36 months

 

European network for the functional analysis of yeast genes discovered by systematic sequencing (phase II) ,

Programme: EUROFAN II - Transport node, E.U.

Principal Investigator of the IST team: Isabel Sá-Correia

Contract: BIO4-CT97-2294

Start date: September 1997

Duration: 24 months

 

European network for the functional analysis of yeast genes discovered by systematic sequencing (phase I) ,

Programme: EUROFAN I -"Six-pack fundamental analysis programme" and "transport node", E.U.

Principal Investigator of the IST team: Isabel Sá-Correia

Contract: BIO4-CT95-0080

Start date: January 1996

Duration: 24 months

 


National Projects (2004-present)

 

CNCVir - The coding and noncoding virulome of Burkholderia cenocepacia

Principal investigator: Jorge Humberto Leitão

Contract: PTDC/MAR-BIO/1547/2014

Start date: 01/04/2016

Duration: 36 months


Harnessing the power of the microbial metamobilome: using marine sponges as models to uncover novel biotechnological appliances from symbiont communities

Principal investigator: Rodrigo da Silva Costa

Contract: PTDC/MAR-BIO/1547/2014

Start date: 01/07/2016

Duration: 36 months


Structural and functional analysis of the Haa1 transcription factor required for yeast response and resistance to acetic acid

Principal investigator at IST: Isabel Sá-Correia 

Contract: PTDC/BBB-BEP/0385/2014

Start date: 01/05/2016

Duration: 36 months


Molecular and Mechanical Forces in Biology measured with Force Feedback Microscopy

Principal investigator at IST: Isabel Sá-Correia 

Contract: PTDC/FIS-NAN/6101/2014

Start date: 01/05/2016

Duration: 36 months


CANTROL - Deciphering the mechanisms of transcriptional regulation that control antifungal drug resistance in the pathogenic yeast Candida glabrata: aiming the development of improved diagnosis and therapeutic approaches

Principal investigator: Miguel Cacho Teixeira 

Contract: PTDC/BBB-BIO/4004/2014

Start date: 01/03/2016

Duration: 36 months


SMARTWINE – Smarter wine fermentations: integrating Omic-tools for the development of novel mixed-starter cultures for tailored-made wine production

Principal investigator at IST: Nuno P Mira 

Contract: PTDC/AGR-TEC/3315/2014

Start date: 01/05/2016

Duration: 36 months


MFS-stress-Major Facilitator Superfamily transporters in the context of modern agriculture constraints: exploratory studies

Principal investigator at IST: Isabel Sá-Correia 

Contract: EXPL/AGR-PRO/1013/2013

Start date: 01/01/2014

Duration: 12 months

 

PhysBioFFM - Biological physics atudies based on Force Feedback Microscopy

Principal investigator at IST: Isabel Sá-Correia 

Contract: EXPL/FIS-NAN/1395/2013

Start date: 01/01/2014

Duration: 12 months

 

PANCANDIDA - Towards the development of novel diagnosis tools for the early detection of invasive infections caused by C. albicans and C. glabrata

Principal investigator: Nuno P Mira 

Contract: Gilead Génese Program

Start date: 01/01/2014

Duration: 24 months


Immunomics-Bcc: Exploitation of immunogenic proteins of the Burkholdeira cepacia complex to design new diagnostic and therapeutic strategies

Principal investigator: Sílvia Sousa 

Contract: PTDC/BBB-BIO/1958/2012

Start date: 01/04/2013

Duration: 36 months


FUNDRING: Identification of new biomarkers for antifungal drug resistance diagnosis in Candida glabrata: the particular role of multidrug resistance transporters

Principal investigator: Miguel Cacho Teixeira

Contract: PTDC/EBB-BIO/119356/2010

Start date: 01/01/2012

Duration: 36 months

 

TerbAzineBiorem - Studies on the efficacy and scale-up of bioremediation strategies for soils contaminated with the herbicide terbuthylazine

Principal investigator: Cristina Anjinho Viegas

Contract: PTDC/AAC-AMB/111317/2009

Start date: 01/01/2011

Duration: 36 months

 

ROOT-INT - Role of a two-component regulatory system in the early interaction between Sinorhizobium meliloti and plant root hairs

Principal investigator: Leonilde M Moreira

Contract: PTDC/BIA-MIC/111733/2009

Start date: 01/01/2011

Duration: 36 months

 

Bacterial protein azurin as a new candidate drug to treat untreatable breast cancers

Principal investigator: Arsénio M Fialho

Contract: PTDC/EBB-BIO/100326/2009

Start date: 01/01/2011

Duration: 36 months

 

Exploiting the type II phosphomannose isomerase BseAJ as a new target for the development of new antimicrobials and biotechnological applications

Principal investigator: Jorge H Leitão

Contract: PTDC/EBB-BIO/098352/2008

Start date: 01/01/2010

Duration: 36 months

 

ZygoSacAR - Mechanistic insights into acetic acid resistance in food spoilage yeasts: from the experimental model Saccharomyces cerevisiae to Zygosaccharomyces species  

Principal Investigator: Isabel Sá-Correia

Contract: PTDC/AGR-ALI/102608/2008

Start date: 01/04/2010

Duration: 36 months

 

QCMTF - Biosensor platform for transcription factor DNA binding activity detection  

Principal Investigator at IST: Isabel Sá-Correia

Contract: PTDC/ EBB-EBI/108517 /2008

Start date: 01/04/2010

Duration: 36 months

 

Resistance to pesticides and other chemical stresses of agricultural interest: role of plant Major Facilitator Superfamily transporters

Principal Investigator at IST: Isabel Sá-Correia

Contract: PTDC/AGR-AAM/102967/2008

Start date: 01/04/2010

Duration: 36 months

 

Imatinib Resistance and Targets in Chronic Myeloid Leukaemia: Post-Genomic Approaches using Yeast as Model System

Principal Investigator: Isabel Sá-Correia

Contract: PTDC/SAU-FCF/71760/2006

Start date: 01/01/2008

Duration: 36 months

 

Characterization and modeling of a specific transcriptional regulatory network required for multidrug resistance in yeast.

Principal Investigator: Isabel Sá-Correia

Contract: PTDC/BIO/72063/2006

Start date: 01/01/2008

Duration: 36 months

 

Functional and biochemical analysis of the yeast multidrug resistance transporters Qdr2 and Aqr1

Principal Investigator: Miguel Cacho Teixeira
Contract: PTDC/BIA-MIC/72577/2006 
Start date: 01/06/2008

Duration: 36 months

 

ARN - Algorithms for the identification of Genetic Regulatory Networks

Principal Investigator of the IST team: Isabel Sá-Correia

Contract: PTDC/EIA/67722/2006

Start date: 01.01.2008

Duration: 36 months

 

Dyablo: models for the dynamic behaviour of Biological Networks

Principal Investigator of the IST team: Isabel Sá-Correia

Contract: PTDC/EIA/71587/2006

Start date: 01.01.2008

Duration: 36 months

 

Optimization and control of intermittent UASB reactors and microbial population dynamics

Principal Investigator of the IST team: Jorge Humberto Leitão

Contract: PTDC/AMB/65025/2006

Start date: 01/01/2008

Duration: 36 months

 

Development of bioassays for herbicide toxicity based on gene expression profiling using yeast cells (HERBITOXBIOAS)

Principal investigator: Cristina Anjinho Viegas

Contract: PTDC/AMB/64230/2006

Start date: 01/11/2007

Duration: 36 months

 

Expression profiling studies to specify the symbiotic genetic programme of the model legume Medicago truncatula

Principal Investigator of the IST team: Leonilde Morais Moreira
Contract: PTDC/AGR-GPL/70592/2006
Start date: 01/10/2007

Duration: 36 months

 

Acute versus persistent infection by Burkholderia cepacia complex bacteria in cystic fibrosis patients: underlying mechanisms, in particular the role of exopolysaccharide biosynthesis

Principal Investigator: Isabel Sá-Correia

Contract: PTDC/SAU-MII/69591/2006

Start date: 01/10/2007

Duration: 36 months

 

Regulation of exopolysaccharide biosynthesis and virulence of Burkholderia cepacia by protein-tyrosine phosphorylation

Principal Investigator: Leonilde Morais Moreira
Contract: PTDC/BIA-MIC/652 10/2006
Start date: 01/09/2007

Duration: 36 months

 

Enzymatic Degradation and Synthesis of Azo and Antraquinonic Dyes
Principal Investigator of the IST team: Cristina Anjinho Viegas
Contract: PTDC/BIO/72108/2006
Start date: 01/09/2007

Duration: 36 months

 

PROBIOETHANOL - Proteomics and engineering of yeast ethanol tolerance for high-productivity bio-ethanol fermentation processes

Principal Investigator of the IST team: Isabel Sá-Correia

Contract: PTDC/BIO/66151/2006

Start date: 01/07/2007

Duration: 36 meses

 

Herbicide resistance in Arabidopsis thaliana: Role of plant multidrug resistance transporters

Principal Investigator of the IST team: Isabel Sá-Correia

Contract: PTDC/AGR-AAM/67858/2006  

Start date: 01/07/2007

Duration: 36 months

 

Role of the exopolysaccharides in the early steps of Rhizobium-legume symbiosis

Principal Investigator: Leonilde Morais Moreira

Contract: PTDC/AGR-AAM/66977/2006

Start date: 01/03/2007

Duration: 36 months

 

 

Biochemical and structural studies of UDP-glucose dehydrogenases

Principal Investigator at IST: Arsénio Mendes Fialho

Contract: PTDC/QUI/67925/2006

Start date: …

Duration: 36 months

 

Insights into the complex regulatory network acting in yeast cells challenged with drugs/chemical stresses: genome-wide expression approaches supported by bioinformatics

Principal Investigator of the IST team: Isabel Sá-Correia

Contract: PDCT/BIO/56838/2004

Start date: 01/01/2006

Duration: 24 months

 

Strategies to accelerate atrazine biodegradation in contaminated soils, waters or sediments and assessment of the ecotoxicity of this herbicide and its metabolites (ATRAZINEBIOREM)

Principal Investigator: Arsénio Mendes Fialho

Contract: POCI/AMB/56039/2004

Start date: 01/09/2005

Duration: 36 months

 

Biosynthesis of the bacterial gum gellan: molecular biology, biochemistry and genetic engineering of the pathway

Principal Investigator: Arsénio Mendes Fialho

Contract: POCTI/BIO/58401/2004

Start date: 01/01/2005

Duration: 36 months

 

DBYeast: Infrastructure and algorithms for analysis and identification of gene regulatory networks

Principal Investigator of the IST team: Isabel Sá-Correia

Contract: POSI/EIA/57398/2004

Start date: 01/01/2005

Duration: 36 months