Papers in international peer-reviewed journals


Alves LG, Pinheiro PF, Feliciano JR, Dâmaso DP, Leitão JH, Martins AM, Synthesis, antimicrobial activity and toxicity to nematodes of cyclam derivatives, International Journal of Antimicrobial Agents, 49(5):646-649, 2017.

Azevedo, L.A., Guerreiro, A.R., Tavares, A.C., Becker, J.D., Moreira, L.M., “The regulator LdhR and the D-lactate dehydrogenase LdhA of Burkholderia multivorans play a role in carbon overflow and in planktonic cellular aggregates formation”. Appl Env. Microbiol. 2017, in press.  doi:10.1128/AEM.01343-17.

Bento JB, Franca RDG, Pinheiro T, Alves LC, Pinheiro HM, Lourenço ND. “Using nuclear microscopy to characterize the interaction of textile-used silver nanoparticles with a biological wastewater treatment system. Nucl Instrum Methods B. 404: 150–154, 2017

Bernardo R, Cunha DV, Wang C, Pereira L, Silva S, Salazar SB, Schroeder MS, Okamoto M, Takahashi-Nakaguchi A, Chibana H, Aoyoama T, Sá-Correia I, Azeredo J, Butler G and Mira NP, "The CgHaa1-regulon mediates response and tolerance to acetic acid stress in the human pathogen Candida glabrata", G3: Genes, Genomes and Genetics, 7(1):1-18, 2017.

Cabral MG, Pereira M, Silva Z, Iria I, Coutinho C, Lopes A, Sá-Correia I, Videira PA, “Using dendritic cells to evaluate how Burkholderia cenocepacia clonal isolates from a chronically infected cystic fibrosis patient subvert immune functions”, Med. Microbiol. Immunol., 206: 111–123, 2017.

Califano G, Castanho S, Soares F, Ribeiro L, Cox CJ, Mata L, Costa R. “Molecular Taxonomic Profiling of Bacterial Communities in a Gilthead Seabream (Sparus aurata) Hatchery” Frontiers in Microbiology 8:204, 2017.

Cardoso JMS, Guerreiro SI, Lourenço A, Alves MM, Montemor MF, Mira NP*, Leitão JH*, Carvalho MFNN*. Ag(I) camphorimine complexes with antimicrobial activity towards clinically important bacteria and species of the Candida genus. PLOS ONE, 12(5):e0177355, 2017. (*co-corresponding authors)

Castanho S, Califano G, Soares F, Costa R, Mata L, Pousão-Ferreira P, Ribeiro L. “The effect of live feeds bathed with the red seaweed Asparagopsis armata on the survival, growth and physiology status of Sparus aurata larvae”, Fish Physiology and Biochemistry 43(4):1043-1054, 2017

Cunha D*, Salazar B*, Lopes MM, Mira NP, Mechanistic insights underlying tolerance to acetic acid stress in vaginal Candida glabrata isolates, Frontiers in Microbiology, 8:259, 2017. (*co-first authors)

Mil-Homens D, Pinto SN, Matos RG, Arraiano C, Fialho AM. "Burkholderia cenocepacia K56-2 trimeric autotransporter adhesin BcaA binds TNFR1 and contributes to induce airway inflammation" Cellular Microbiology.19(4), 2017, doi: 10.1111/cmi.12677.

Gil FN, Belli G, Viegas CA. The Saccharomyces cerevisiae response to stress caused by the herbicidal active substance alachlor requires the iron regulon transcription factor Aft1p. Environmental Microbiology, 19(2):485-499, 2017.

Godinho, C.P., Mira, N.P., Cabrito, T.R., Teixeira, M.C., Alasoo, K., Guerreiro, J. F., Sá-Correia, I., “Yeast response and tolerance to benzoic acid involves the Gcn4- and Stp1- regulated multidrug/multixenobiotic resistance transporter Tpo1”, Applied Microbiology and Biotechnology, 101(12), 5005-5018, 2017.

Grueneberg, J., Engelen, A. H., Costa, R., Wichard, T., “Macroalgal morphogenesis induced by waterborne compounds and bacteria in coastal seawater”, PLoS ONE, 11: e0146307, 2016.Guerreiro, J.F.*, Mira, N.P.*, dos Santos, A.X.S, Riezman, H., Sá-Correia, I. "Membrane phosphoproteomics of yeast early response to acetic acid: role of Hrk1 kinase and lipid biosynthetic pathways, in particular sphingolipids", Frontiers in Microbiology, 2017, accepted for publication. (*co-first authors)

Guerreiro, J.F., Mira, N.P., Santos, A.X.S., Riezman, H., Sá-Correia, I., "Membrane phosphoproteomics of yeast early response to acetic acid: Role of Hrk1 kinase and lipid biosynthetic pathways, in particular sphingolipids", Frontiers in Microbiology, in press, doi: 10.3389/fmicb.2017.01302

Hassan AA, Maldonado RF, Dos Santos SC, Di Lorenzo F, Silipo A, Coutinho CP, Cooper VS, Molinaro A, Valvano MA, Sá-Correia I. "Structure of O-Antigen and Hybrid Biosynthetic Locus in Burkholderia cenocepacia Clonal Variants Recovered from a Cystic Fibrosis Patient", Frontiers in Microbiology, 8:1027, 2017.

Henriques SF, Mira NP, Sá-Correia I, Genome-wide search for candidate genes for yeast robustness improvement against formic acid reveals novel susceptibility (Trk1 and positive regulators) and resistance (Haa1-regulon) determinants, Biotechnology for Biofuels, 10:19, 2017. 

Karimi, E., Gonçalves, J.M:S., Reis, M., Costa, R., "Draft genome sequence of Microbacterium sp. strain Alg239_V18, an Actinobacterium retrieved from the marine sponge Spongia sp.", Genome Announcements, 5: e01457-16, 2017.

Mil-Homens D, Pinto SN, Matos RG, Arraiano C, Fialho AM, "Burkholderia cenocepacia K56-2 trimeric autotransporter adhesin BcaA binds TNFR1 and contributes to induce airway inflammation", Cellular Microbiology, doi: 10.1111/cmi.12677.

Monteiro PT, Pais P, Costa C, Manna S, Sá-Correia I,Teixeira MC, "The PathoYeastract database: an information system for the analysis of gene and genomic transcription regulation in pathogenic yeasts", Nucleic Acids Research, 45:D597-D603, 2017.

Napoleão, P., Carmo, M.M., Pinheiro, T., "Prognostic evaluation of soluble CD40L in acute myocardial infarction: is not fancy, is science!", Ann. Transl. Med., 5: 90, 2017.

Palma M, Dias PJ, Roque FC, Luzia L, Guerreiro JF, Sá-Correia I, The Zygosaccharomyces bailii transcription factor Haa1 is required for acetic acid and copper stress responses suggesting subfunctionalization of the ancestral bifunctional protein Haa1/Cup2, BMC Genomics, 18(1):75, 2017.

Palma, M., Münsterkötter, M., Peça, J., Güldener, U., Sá-Correia, I. "Genome sequence of the highly weak-acid-tolerant Zygosaccharomyces bailii IST302, amenable to genetic manipulations and physiological studies". FEMS Yeast Res. 2017 doi: 10.1093/femsyr/fox025.

Ribeiro N, Roy S, Butenko N, Cavaco I, Pinheiro T, Alho I, Marques F, Avecilla F, Costa Pessoa J Correia I. New Cu(II) complexes with pyrazolyl derived Schiff base ligands: Synthesis and biological evaluation. Journal of Inorganic Biochemistry 174:63–75, 2017.

Remy E, Niño-González M, Godinho C, Cabrito TR, Teixeira MC, Sá-Correia I, Duque P, Heterologous expression of the yeast Tpo1p or Pdr5p membrane transporters in Arabidopsis confers plant xenobiotic tolerance, Scientific Reports, 7(1):4529, 2017.

Santos R, Costa C, Mil-Homens D, Romão D, de Carvalho CCR, Pais P, Mira NP, Fialho AM, Teixeira MC, "The multidrug resistance transporters CgTpo1_1 and CgTpo1_2 play a role in virulence and biofilm formation in the human pathogen Candida glabrata", Cellular Microbiology, e12686, 2017.

Seixas I, Barbosa C, Salazar SB, Mendes-Faia A, Wang Y, Guldener U, Mendes-Ferreira A*, Mira NP*, Genome sequence of the non-conventional yeast Hanseniaspora guilliermondii UTAD222, Genome Announcements, 5(5) e01515-16, 2017. (* co-corresponding authors)

Silva IN, Duarte S, Moreira LM, Monteiro GA. "Draft Genome Sequence of the Plasmid-Free Lactococcus lactis subsp. lactis Strain LMG 19460" Genome Announcements. 5(16). pii: e00210-17, 2017.

Silva IN, Ramires MJ, Azevedo LA, Guerreiro AR, Tavares AC, Becker JD, Moreira LM. "The regulator LdhR and the d-lactate dehydrogenase LdhA of Burkholderia multivorans play a role in carbon overflow and in planktonic cellular aggregates formation" Applied and Environmental Microbiology. pii: AEM.01343-17, 2017.

Sousa SA, Feliciano JR, Pita T, Guerreiro SI, Leitão JH, "Burkholderia cepacia complex virulence gene expression regulation: a review", Genes 8:43, 2017. 

Swinnen S*, Henriques SCF*, Shrestha R, Ho PW, Sá-Correia I**, Nevoigt E**, Improvement of yeast tolerance to acetic acid through Haa1 transcription factor engineering: towards the underlying mechanisms, Microbial Cell Factories, 16:7, 2017. (*co-first;**co-correspondent) 

Vasco MS, Alves LC, Corregidor V, Correia D, Godinho CP, Sá-Correia I, Bettiol A, Watt F, Pinheiro T. "3D map distribution of metallic nanoparticles in whole cells using MeV ion microscopy" Journal of Microscopy, 267(2):227-236, 2017. 

Weiss A, Costa R, Wichard T, Morphogenesis of Ulva mutabilis (Chlorophyta) induced by Maribacter species (Bacteroidetes, Flavobacteriaceae). Botanica Marina 60: 197-206, 2017.


Alves MM, Cunha DV, Santos CF, Mira NP, Montemor MF, In vitro corrosion behaviour and anti-Candida spp. activity of Zn coated with ZnO-nanostructured ‘Anastacia’ flowers, J Mat. Chem. B, 4:4754, 2016.    

Araujo R, Caramalho R, Coutinho C, Sá-Correia I. "SNaPBceBcon: a practical tool for identification and genotyping of Burkholderia cepacia and Burkholderia contaminans". J Clin Microbiol. 2:483-488, 2016. 

Bernardes N, Abreu S, Carvalho FA, Fernandes F, Santos NC, Fialho AM "Modulation of membrane properties of lung cancer cells by azurin enhances the sensitivity to EGFR-targeted therapy and decreased β1 integrin-mediated adhesion" Cell Cycle, 15(11):1415-24, 2016.

Cardoso JM, Galvão AM, Guerreiro SI, Leitão JH, Suarez AC, Carvalho MF, "Antibacterial activity of silver camphorimine coordination polymers", Dalton Trans, 45(16):7114-23, 2016.

Coelho FJRC, Cleary DFR, Costa R, Ferreira M, Polónia ARM, Silva AMS, Simões MMQ, Oliveira V, Gomes NCM, Multi-taxon activity profiling reveals differential microbial response to reduced seawater pH and oil pollution. Molecular Ecology, 25: 4645–4659, 2016.

Costa C, Ribeiro J, Miranda IM, Silva-Dias AI, Cavalheiro M, Costa-de-Oliveira S, Rodrigues AG, Teixeira MC, "Clotrimazole drug resistance in Candida glabrata clinical isolates correlates with increased expression of the drug:H+ antiporters CgAqr1, CgTpo1_1, CgTpo3 and CgQdr2", Frontiers in Microbiology, 7:526, 2016. 

Cúcio ACB, Engelen AH, Costa R, Muyzer G, Rhizosphere microbiomes of European seagrasses are not species-specific, but shaped by their environment. Frontiers in Microbiology 7:440, 2016. doi: 10.3389/fmicb.2016.00440.

Feliciano JR, Grilo AM, Guerreiro SI, Sousa SA, Leitão JH, "Hfq: a multifaceted RNA chaperone involved in virulence", Future Microbiology, 11:137-51, 2016.

Ferreira RA, Roma-Rodrigues C, Davies LC, Sá-Correia I, Martins-Dias S, A quantitative proteomic approach to highlight Phragmites sp. adaptation mechanisms to chemical stress induced by a textile dyeing pollutant, Science of The Total Environment, 573, 788, 2016.

Fialho AM, Bernardes N, Chakrabarty AM "Exploring the anticancer potential of the bacterial protein azurin" AIMS Microbiology 2(3):292-303, 2016.

Franco T, Califano G, Gonçalves AC, Cúcio C, Costa R. “Draft Genome Sequence of Vibrio sp. Strain Evh12, a Bacterium Retrieved from the Gorgonian Coral Eunicella verrucosa.” Genome Announcements 4(1). pii: e01729-15, 2016.

Guerreiro J, Muir A, Ramachandran S, Thorner J, Sá-Correia I, Sphingolipid biosynthesis upregulation by TOR Complex 2-Ypk1 signaling during yeast adaptive response to acetic acid stress, Biochemical Journal 473(23): 4311-4325, 2016. (*co-first;**co-correspondent)

Guerreiro JF, Sampaio-Marques B, Soares R, Coelho AV, Leão C, Ludovico P, Sá-Correia I, "Mitochondrial proteomics of the acetic acid – induced programmed cell death response in a highly tolerant Zygosaccharomyces bailii – derived hybrid strain". Microbial Cell, 3(2): 65-78, 2016. 

Keller-Costa T, Silva R, Lago-Lestón A, Costa R, Genomic insights into Aquimarina sp. strain EL33, a bacterial symbiont of the gorgonian coral Eunicella labiataGenome Announcements (2016). doi:10.1128/genomeA.00855-16.

Maldonado R, Sá-Correia I, Valvano M, "Lipopolysaccharide modification in Gram-negative bacteria during chronic infection", FEMS Microbiology Reviews, 40(4): 480-493, 2016.

Mil-Homens D, Ferreira-Dias S, Fialho AM, "Fish oils against Burkholderia and Pseudomonas aeruginosa: in vitro efficacy and their therapeutic and prophylactic effects on infected Galleria mellonella larvae", Journal of Applied Microbiology, 120(6):1509-19, 2016.

Moreira AS, Lourenço AB, Sá-Correia I, 1H-NMR-based endometabolome profiles of Burkholderia cenocepacia clonal variants retrieved from a cystic fibrosis patient during chronic infection, Frontiers in Microbiology, 7:2024, 2016.

Moreira AS, Mil-Homens D*, Sousa SA*, Coutinho CP*, Pinto-de-Oliveira A, Ramos CG, dos Santos SC, Fialho AM, Leitão JH, Sá-Correia I. Variation of Burkholderia cenocepacia virulence potential during cystic fibrosis chronic lung infection. Virulence, doi:10.1080/21505594.2016.1237334 (in press).

Napoleão P, Cabral LB, Selas M, Freixo C, Monteiro MD, Criado MB, Costa MC, Enguita FJ, Viegas-Crespo AM, Saldanha C, Carmo MM, Ferreira RC, Pinheiro T. “Stratification of ST-elevation myocardial infarction patients based on soluble CD40L longitudinal changes” Translational Research 176:95-104, 2016.
Pais P, Costa C, Cavalheiro M, Romão D, Teixeira MC, "Transcriptional control of drug resistance, virulence and immune system evasion in pathogenic fungi: a cross-species comparison", Frontiers in Cellular and Infection Microbiology, 6:131, 2016.

Pais P, Costa C, Pires C, Shimizu K, Chibana H, Teixeira MC, “Membrane proteome-wide response to the antifungal drug clotrimazole in Candida glabrata: role of the transcription factor CgPdr1 and the Drug:H+ Antiporters CgTpo1_1 and CgTpo1_2”, Molecular and Cellular Proteomics, 15(1):57-72, 2016.

Pais, P., Pires, C., Costa, C., Okamoto, M., Chibana, H., Teixeira, M.C., “Membrane proteomics analysis of the Candida glabrata response to 5-flucytosine: unveiling the role and regulation of the drug efflux transporters CgFlr1 and CgFlr2”, Frontiers in Microbiology, 7:2045, 2016.

Rotini A, Mejia A, Costa R, Migliore L, Winters G, The seagrass holobiont Halophila stipulacea: ecophysiological plasticity and bacteriome structure along a depth gradient (4 - 28 m) in the Northern Red Sea. Frontiers in Plant Science 7:2015, 2016.

Silva, I.N., Santos, P.M., Santos, M.R., Zlosnik, J.E.A., Speert, D.P., Buskirk, S.W., Bruger, E.L., Waters, C.M., Cooper, V.S., Moreira, L.M., “Long-term evolution of Burkholderia multivorans during a chronic cystic fibrosis infection reveals shifting forces of selection”, mSystems 1: e00029-16, 2016

Sousa SA, Leitão JH, Martins RC, Sanches JM, Suri JS, Giorgetti A, "Bioinformatics Applications in Life Sciences and Technologies", Biomed Res Int, 2016:3603827, 2016.

Sousa SA, Morad M, Feliciano JR, Pita T, Nady S, El-Hennamy RE, Abdel-Rahman M, Cavaco J, Pereira L, Barreto C, Leitão JH, "The Burkholderia cenocepacia OmpA-like protein BCAL2958: identification, characterization, and detection of anti-BCAL2958 antibodies in serum from B. cepacia complex-infected Cystic Fibrosis patients". AMB Express, 6(1):41, 2016. 
Thomas, T., Moitinho-Silva, L., Lurgi, M., Björk, J. R., Easson, C., Astudillo-Garcia, C., Olson, J., Erwin, P., Lopez-Legentil, S., Luter, H., Chaves-Fonnegra, A., Costa, R., Schupp, P., Steindler, L., Erpenbeck, D., Gilbert, J., Knight, R., Ackerman, G., Lopez, J., Taylor, M., Thacker, R.W., Montoya, J., Hentschel, U., Webster, N. “Diversity, structure and convergent evolution of the global sponge microbiome”. Nature Communications. 7: 11870, 2016.


Barbosa C, Mendes-Faia A, Lage P, Mira NP, Mendes-Ferreira A. Genomic expression program of Saccharomyces cerevisiae along a mixed-culture wine fermentation with Hanseniaspora guilliermondii. Microb Cell Fact. 14(1):124, 2015. 

Costa, C., Ponte, A., Pais, P., Santos, R., Cavalheiro, M., Takashi, Y., Chibana, H., Teixeira, M.C., "New mechanisms of flucytosine resistance in C. glabrata unveiled by a chemogenomics analysis in S. cerevisiae", PLoS ONE, 10(8):e0135110, 2015.

Coutinho CP, Barreto C, Pereira L, Lito L, Melo Cristino J, Sá-Correia I. Incidence of Burkholderia contaminans at a cystic fibrosis centre with an unusually high representation of Burkholderia cepacia during 15 years of epidemiological surveillance. J Med Microbiol. 64(8):927-35, 2015.

Cullen, L., Weiser, R., Olszak, T., Maldonado, R.F., Moreira, A.S., Slachmuylders, L., Brackman, G., Paunova-Krasteva, T.S., Zarnowiec, P., Czerwonka, G., Reilly, J., Drevinek, P., Kaca, W., Melter, O., de Soyza, A., Perry, A., Winstanley, C., Stoitsova, S.R., Lavigne, R., Mahenthiralingam, E., Sá-Correia, I., Coenye, T., Drulis-Kawa, Z., Augustyniak, D., Valvano, M.A., McClean, S., "Phenotypic characterisation of an international Pseudomonas aeruginosa reference panel: Strains of cystic fibrosis origin show less in vivo virulence than non-CF strains", Microbiology, 161(10):1961-77.

dos Santos, S.C., Sá-Correia, I., "Yeast toxicogenomics: lessons from a eukaryotic cell model and cell factory", Current Opinion in Biotechnology 33:183–191, 2015.

Ferreira AS, Silva IN, Fernandes F, Pilkington R, Callaghan M, McClean S, Moreira LM. "The tyrosine kinase BceF and the phosphotyrosine phosphatase BceD of Burkholderia contaminans are required for efficient invasion and epithelial disruption of a cystic fibrosis lung epithelial cell line", Infect Immun. 83(2):812-21, 2015.

Gil, F.N., Moreira-Santos, M., Chelinho, S., Pereira, C., Feliciano, J.R., Leitão, J.H., Sousa, J.P., Ribeiro, R., Viegas, C.A., "Suitability of a Saccharomyces cerevisiae-based assay to assess the toxicity of pyrimethanil sprayed soils via a surface runoff: comparison with aquatic and soil toxicity assays", Science of the Total Environment, 505: 161-171, 2015.

Lourenço, N.D., Franca, R.D.G., Moreira, M.A., Gil, F.N., Viegas, C.A., Pinheiro, H.M. Comparing aerobic granular sludge and flocculent sequencing batch reactor technologies for textile wastewater treatment, Biochemical Engineering Journal, 104: 57-63, 2015.

Palma, P., Roque, F.C., Guerreiro, J., Mira, N.P., Queiroz, L., Sá-Correia, I., "Search for genes responsible for the remarkably high acetic acid tolerance of a Zygosaccharomyces bailii-derived interspecies hybrid strain", BMC Genomics 16:1070, 2015.

Remy, E., Cabrito, T.R., Baptista, R.A., Teixeira M.C., Sá-Correia, I., Duque, P., "The Major Facilitator Superfamily transporter ZIFL2 modulates cesium and potassium homeostasis in Arabidopsis", Plant and Cell Physiology,  56 (1), 148-162, 2015.

Silva IN, Santos PM, Moreira LM., "Draft Genome Sequences of Two Burkholderia multivorans Sequential Isolates from a Chronic Lung Infection of a Cystic Fibrosis Patient", Genome Announc. 3(1). pii: e01531-14, 2015. 

Silva, Vera P., Moreira-Santos, M., Mateus, C., Teixeira, T., Ribeiro, R., Viegas, C.A., Evaluation of Arthrobacter aurescens strain TC1 as bioaugmentation bacterium in soils contaminated with the herbicidal substance terbuthylazine. PLoS ONE 10(12):e0144978, 2015.

Tyrrell J., Whelan N., Wright C., Sá-Correia I., McClean S., Thomas M., Callaghan M., "Investigation of the multifaceted iron acquisition strategies of Burkholderia cenocepacia", Biometals, 28 (2), 367-380, 2015.

Trček J, Mira NP, Jarboe LR. Adaptation and tolerance of bacteria against acetic acid. Appl Microbiol Biotechnol. 99(15):6215-29, 2015.



Bernardes, N., Ribeiro, A.S., Abreu, S., Vieira, A.F., Carreto, L., Santos, M., Seruca, R., Paredes, J., Fialho, A.M., "High-throughput molecular profiling of a P-cadherin overexpressing breast cancer model reveals new targets for the anti-cancer bacterial protein azurin", The International Journal of Biochemistry and Cell Biology, 50: 1-9, 2014.

Chakrabarty, A.M., Bernardes, N., Fialho, A.M., "Bacterial proteins and peptides in cancer therapy: today and tomorrow", Bioengineered, 5(4): 427-435, 2014.

Costa, C., Nunes, J., Henriques, A., Mira, N.P., Nakayama, H., Chibana, H., Teixeira, M.C., "The Candida glabrata drug:H+ antiporter CgTpo3 (ORF CAGL0I10384g): role in azole drug resistance and polyamine homeostasis", Journal of Antimicrobial Chemotherapy, 69:1767-76, 2014.

Costa, C., Dias, P.J., Sá-Correia, I., Teixeira, M.C., "MFS multidrug transporters in pathogenic fungi: do they have real clinical impact?", Frontiers in Physiology, 5:197, 2014.

de Carvalho, J., Rodrigues, R.M.M., Tomé, B., Henriques, S.F., Mira, N.P., Sá-Correia, I., Ferreira, G.N.M., Conformational and Mechanical changes of DNA upon transcription factor binding detected by a QCM and transmission line model, Analyst, 139(8): 1847-55, 2014.

Dias, P.J., Sá-Correia, I., "Phylogenetic and syntenic analyses of the 12-spanner drug:H+ antiporter family 1 (DHA1) in pathogenic Candida species: evolution of MDR1 and FLU1 genes", Genomics, 104(1): 45-57, 2014.

dos Santos, S.C., Teixeira, M.C., Dias, P.J., Sá-Correia, I., MFS transporters required for multidrug/multixenobiotic (MD/MX) resistance in the model yeast: understanding their physiological function through post-genomic approaches, Frontiers in Physiology, 5:180, 2014.

Gil, F.N., Becker, J.D., Viegas, C.A., "Potential mechanisms underlying response to effects of the fungicide pyrimethanil from gene expression profiling in Saccharomyces cerevisiae", Journal of Agricultural and Food Chemistry, 62(23): 5237-47, 2014.

Mil-Homens, D., Leça, M.I., Fernandes, F., Pinto, S.N., Fialho, A.M., "Characterization of BCAM0224, a multifunctional trimeric autotransporter from the human pathogen Burkholderia cenocepacia", Journal of Bacteriology, 119(11): 1986-79, 2014.

Mira, N.P., Münsterkötter, M., Dias-Valada, F., Santos, J., Palma, M., Roque, F., Guerreiro, J., Rodrigues, F., Sousa, M.J., Leão, C., Guldener, U., Sá-Correia, I., "The genome sequence of the highly acetic acid-tolerant Zygosaccharomyces bailii derived interspecies hybrid strain ISA1307, isolated fom a sparkling wine plant, DNA Research, 21(3): 299-313, 2014. 

Moreira, A.S., Coutinho, C.P., Azevedo, P., Lito, L., Melo-Cristino, J., Sá-Correia, I., Burkholderia dolosa phenotypic variation during the decline in the lung function of a cystic fibrosis patient along 5.5 years of chronic colonization. Journal of Medical Microbiology, 63: 594-601, 2014.

Pereira, F.B., Teixeira, M.C., Mira, N.P., Sá-Correia, I., Domingues, L., "Genome-wide screening of Saccharomyces cerevisiae genes required to foster tolerance towards industrial wheat straw hydrolysates", Journal of Industrial Microbiology & Biotechnology, 41: 1753-61, 2014.

Pereira, S.G.,Rosa, A.C., Ferreira, A.S., Moreira, L.M., Proença, D.N., Morais, P.V., Cardoso, O., "Virulence factors and infection ability of Pseudomonas aeruginosa isolates from a hydropathic facility and respiratory infections", Journal of Applied Microbiology, 116(5): 1359-68, 2014.

Ramos, C.G., Grilo, A.M., Sousa, S.A., Feliciano, J.R., da Costa, P.J., Leitão, J.H., "Regulation of Hfq mRNA and protein levels in Escherichia coli and Pseudomonas aeruginosa by the Burkholderia cebocepacia MtvR sRNA", PLoS One, 9(6): e98813, 2014.

Remy, E., Cabrito, T.R., Batista, R.A., Hussein, M.A.M., Teixeira, M.C., Athanasiadis, A., Sá-Correia, I., Duque, P., "Intron retention in the 5'UTR of the novel ZIF2 transporter enhances translation to promote zinc tolerance in Arabidopsis", PLoS Genetics, 10(5):e1004375, 2014.

Rodrigues, R.M., de-Carvalho, J., Henriques, S.F., Mira, N.P., Sá-Correia, I., Ferreira, G.N., "Transmission line model analysis of transcription factors binding to oligoduplexes - differentiation of the effect of single nucleotide modifications", Analyst, 139(16): 3871-4, 2014.

Santos, M.R., Marques, A.T., Becker, J.D., Moreira, L.M., "The Sinorhizobium meliloti EmrR regulator is required for efficient colonization of Medicago sativa root nodules" Molecular Plant-Microbe Interactions, 27: 388-399, 2014.

Sousa, S.A., Feliciano, J.R., Grilo, A.M., Leitão, J.H., "Bioinformatics: a molecular microbiologist's perspective", Current Bioinformatics, 9: 8-17, 2014.

Teixeira, M.C., Monteiro, P.T., Guerreiro, J.F., Gonçalves, J.P., Mira, N.P., dos Santos, S.C., Cabrito, T., Palma, M., Costa, C., Francisco, A.P., Madeira, S.C., Oliveira, A.L., Freitas, A.T., Sá-Correia, I., "The YEASTRACT database: an upgraded information system for the analysis of gene and genomic transcription regulation in Saccharomyces cerevisiae", Nucleic Acids Research, Database Issue, 42: D161-D166, 2014.




Barbas, A., Popescu, A., Frazão, C., Arraiano, C.M., Fialho, A.M., "Rossmann-fold motifs can confer multiple functions to metabolic enzymes: RNA binding and ribonuclease activity of a UDP-glucose dehydrogenase", Biochemical & Biophysical Research Communications, 430(1):218-24, 2013.

Bernardes, N., Robeiro, A.S., Abreu, S., Mota, B., Matos, R.G., Arraiano, C.M., Seruca, R., Paredes, J., Fialho, A.M., "The bacterial protein azurin impairs invasion and FAK/Src signaling in P-cadherin-overexpressing breast cancer cell models", PLoS One, 8(7):e69023, 2013.

Bernardes, N., Chakrabarty, A.M., Fialho, A.M., "Engineering of bacterial strains and their products for cancer therapy", Applied Microbiology and Biotechnology, 97(12):5189-99, 2013.

Costa, C., Pires, C., Cabrito, T.R., Renaudin, A., Ohno, M., Chibana, H., Sá-Correia, I., Teixeira, M.C., "Candida glabrata drug:H+ antiporter CgQdr2 (ORF CAGL0G08624g) confers imidazole drug resistance, being activated by the CgPdr1 transcription factor", Antimicrobial Agents and Chemotherapy, 57(7):3159-67, 2013.

Costa, C., Henriques, A.S., Pires, C., Nunes, J., Ohno, M., Chibana, H., Sá-Correia, I., Teixeira, M.C., "The dual role of Candida glabrata Drug:H+ Antiporter CgAqr1 (ORF CAGL0J09944g) in antifungal drug and acetic acid resistance", Frontiers in Microbiology, 4:170, 2013.

Dias, P.J., Sá-Correia, I., "The drug:H+ antiporters of family 2 (DHA2), siderophore transporters (ARN) and glutathione:H+ antiporters (GEX) have a common evolutionary origin in hemiascomycete yeasts, BMC Genomics, 14: 901.

De Soyza, A., Hall, A., Mahenthiralingam, E., Drevinek, P., Kaca, W., Drulis-Kawa, Z., Stoitsova, S., Toth, V., Coenye, T., Zlosnik, J., Burns, J., Sá-Correia, I., De Vos, D., Pirnay, J.P., Kidd, T., Reid, D., Manos, J., Lockgether, J., Wiehlmann, L., Tummler, B., McClean, S., Winstanley, C., "Developing an international Pseudomonas aeruginosa reference panel", Microbiology Open, 2(6): 1010-1023, 2013.

Di Lorenzo, F., Silipo, A., Lanzetta, R., Fazio, L.L., Paciello, I., Coutinho, C.P., Sá-Correia, I., Bernardini, M., Molinaro, A., "Chemistry and Biology of the Potent Endotoxin from a Burkholderia dolosa Clinical Isolate from a Cystic Fibrosis Patient". ChemBioChem, 14(9): 1105-15, 2013.

El-Kirat, S., Mil-Homens, D., Beaussart, A., Fialho, A.M., Dufrêne, Y.F., "Single-molecule atomic force microscopy unravels the binding mechanism of a Burkholderia cenocepacia trimeric autotransporter adhesin", Molecular Microbiology, 89(4):649-59, 2013.

Eusébio, N., Coutinho, C., Sá-Correia, I., Araújo, R., "SNaPBcen: a novel and practical tool for genotyping Burkholderia cenocepacia", Journal of Clinical Microbiology, 51(8): 2646-53, 2013.

Ferreira, A.S., Silva, I.N., Oliveira, V.H., Becker, J.D., Givskov, M., Ryan, R.P., Fernandes, F., Moreira, L.M., "Comparative transcriptomic analysis of the Burkholderia cepacia tyrosine kinase bceF mutant reveals a role in tolerance to stress, biofilm formation and virulence", Applied and Environmental Microbiology, 79(9):3009-20, 2013.

Lourenço, A.B., Roque, F.C., Teixeira, M.C., Ascenso, J.R., Sá-Correia, I., "Quantitative 1H-NMR-metabolomics reveals extensive metabolic reprogramming and the effect of the aquaglyceroporin FPS1 in ethanol stressed yeast cells", PLoS One, 8 (2): e55439, 2013.

Madeira, A., dos Santos, A.C., Santos, P.M., Coutinho, C.P., Tyrrell, J., McClean, S., Callaghan, M., Sá-Correia, I., Proteomic profiling of Burkholderia cenocepacia clonal isolates with different virulence potential retrieved from a cystic fibrosis patient during chronic lung infection, PLOS ONE 8(12): e83065, 2013.

Mira, N.P., Teixeira, M.C., 2013, "Microbial mechanisms of tolerance to weak acid stress", Frontiers in Microbiology (Editorial), 4, 416.

Ramos, C.G., Grilo, A.M., da Costa, P.J., Leitão, J.H., "Experimental identification of small non-coding regulatory RNAs in the opportunistic human pathogen Burkholderia cenocepacia", Genomics. 101: 139-148, 2013.

Remy, E., Cabrito, T.R., Baster, P., Batista, R.A., Teixeira, M.C., Friml, J., Sá-Correia, I., Duque, P., "A Major Facilitator Superfamily Transporter Plays a Dual Role in Polar Auxin Transport and Drought Stress Tolerance in Arabidopsis", The Plant Cell, 25: 901-26, 2013.

Silva, I.N., Tavares, A.C., Ferreira, A.S., Moreira, L.M., "Stress conditions triggering mucoid morphotype variation in Burkholderia species and effect on virulence in Galleria mellonella and biofilm formation in vitro", PLoS One, 8(12):e82522, 2013.

Sousa, S.A., Feliciano, J.R., Pinheiro, P.F., Leitão J.H., "Biochemical and functional studies on the Burkholderia cepacia complex bceN gene, encoding a GDP-mannose 4,6-dehydratase", PLoS One. 2013;8(2):e56902, 2013.

Viegas, S.C., Mil-Homens, D., Fialho, A.M., Arraiano, C.M., "The virulence of Salmonella enterica serovar typhimurium in the insect model Galleria mellonella is impaired by mutations in RNase E and RNase III", Applied and Environmental Microbiology, 79(19): 6124-33, 2013.



Avner, B.S., Fialho, A.M., Chakrabarty, A.M., "Overcoming drug resistanc in multi-drug resistant cancers and microorganisms: a conceptual framework", Bioengineered Bugs, 3(5), 2012.

Chelinho, S., Moreira-Santos, M., Silva, C., Costa, C., Viana, P., Viegas, C.A., Fialho, A.M., Ribeiro, R., Sousa, J. P., "Semi-field testing of a bioremediation tool for atrazine contaminated soils: evaluating the efficacy on soil and aquatic compartments", Environmental Toxicology and Chemistry, 31(7), 1564-1572, 2012.

Fialho AM, Salunkhe P, Manna SK, Mahali S, Chakrabarty AM, "Glioblastoma Multiforme: Novel Therapeutic Approaches" ISRN Neurology, Article ID 642345, 2012.

Fialho, A.M., Bernardes, N., Chakrabarty, A.M., "Recent patents on live bacteria and their products as potential anticancer agents", Recent Patents on Anti-Cancer Drug Discovery, 31-55, 2012.

Fialho, A.M., Chakrabarty, A.M., "Patent controversies and court cases: cancer diagnosis, therapy and prevention", Cancer Biology Therapy, 13 (13), 2012.

Guerreiro, J., Mira, N.P., Sá-Correia, I., "Adaptive response to acetic acid in the highly resistant species Zygosaccharomyces bailiirevealed by quantitative proteomics", PROTEOMICS, 12: 2303-18, 2012.

Madeira, A., da Silva, C.L, dos Santos, F., Camafeita, E., Cabral, J.M.S., Sá-Correia, I., "Human Mesenchymal Stem Cell Expression program upon extended ex-vivo cultivation as revealed by 2-DE-Based quantitative proteomics", PLOS One, 7(8), 2012.

Matos, R.G.,Fialho, A.M., Giloh, M., Schuster, G., Arraiano, C.M., "The rnb gene of Synechocystis PCC6803 encodes a RNA hydrolase displaying RNase II and not RNase R enzymatic properties", PLoS One, 7: e32690, 2012.

Mil-Homens, D., Fialho, A.M.,"A BCAM0223 mutant of Burkholderia cenocepacia is defficient in hamagglutination, serum resistance, adhesion to epothelial cells and virulence", PLoS One, 7: e41747, 2012.

Mil-Homens, D., Bernardes, N., Fialho, A.M., "The antibacterial properties of docosahexaenoic omega-3 fatty acid against the Cystic Fibrosis multi-resistant pathogen Burkholderia cenocepacia", FEMS Microbiology Letters, 328: 61-69, 2012.

Palma, M., Madeira, S.C, Mendes-Ferreira, A., Sá-Correia, I., "Impact of assimilable nitrogen availability in glucose uptake kinetics in Saccharomyces cerevisiae during alcoholic fermentation", Microbial Cell Factories, 11(1):99, 2012.

Ramos, C.G., da Costa, P.J., Döring, G., Leitão, J.H., "The novel cis-encoded small RNA h2cR is a negative regulator of hfq2 in Burkholderia cenocepacia", PLoS One. 7(10):e47896, 2012.

Remy, E., Cabrito, T.R., Baptista, R.A., Teixeira, M.C., Sá-Correia, I., Duque, P., "The Pht1;9 and Pht1;8 transporters mediate inorganic phosphate acquisition by the Arabidopsis thaliana root during phosphorus starvation", New Phytologist, 195: 356-71, 2012.

dos Santos, S.C., Mira, N.P., Moreira, A.S., Sá-Correia, I., "Quantitative- and phospho-proteomic analysis of the yeast response to the tyrosine kinase inhibitor imatinib", OMICS: A Journal of Integrative Biology, 16(10), 537-551, 2012.

dos Santos, S.C., Teixeira, M.C., Cabrito, T.R., Sá-Correia, I., "Yeast Toxicogenomics: genome-wide responses to chemical stresses with impact in Environmental Health, Pharmacology and Biotechnology", Frontiers in Genetics, 3, 63, 2012.

Teixeira, M.C., Godinho, C.P., Cabrito, T.R., Mira, N.P., Sá-Correia, I., Increased expression of the yeast multidrug resistance ABC transporter Pdr18 leads to increased ethanol tolerance and ethanol production in high gravity alcoholic fermentation, Microbial Cell Factories, 11, 98, 2012.

Viegas, C.A., Costa, C., André, S., Viana, P., Ribeiro, R., Moreira-Santos, M., "Does S-metolachlor affect the performance of Pseudomonassp. strain ADP as bioaugmentation bacterium for atrazine-contaminated soils?" PLoS ONE, 7(5), e37140, 2012.



Abdulrehman D., Monteiro P.T., Teixeira M.C., Mira N.P., Lourenço A.B., dos Santos S.C., Cabrito T.R., Francisco A., Madeira S.C., Santos R., Oliveira, A.L., Sá-Correia I., Freitas A. T., "YEASTRACT: Providing a programmatic access to curated transcriptional regulatory associations in Saccharomyces cerevisiaethrough a web services interface." Nucleic Acids Research, 39, D136-140, 2011.

Cabrito, T.R., Teixeira, M.C., Singh, A., Prasad, R., Sá-Correia, I., "The yeast ABC transporter Pdr18 (ORF YNR070w) controls plasma membrane sterol composition, playing a role in multidrug resistance", Biochemical Journal, 440, 195-202, 2011.

Coutinho C.P., de Carvalho C.C.C.R., Madeira A., Pinto-de-Oliveira A., Isabel Sá-Correia I., "Burkholderia cenocepaciaphenotypic clonal variation during three and a half years of residence in the lungs of a cystic fibrosis patient". Infection and Immunity, 79: 2950-60, 2011.

Coutinho, C.P., dos Santos, S.C., Madeira, A., Mira, N.P., Moreira, A.S., Sá-Correia, I., "Long-term colonization of the cystic fybrosis lung by Burkholderia cepaciacomplex bacteria: epidemiology, clonal variation and genome-wide expression alterations", Frontiers in Cellular and Infection Microbiology,1, article 12, 2011.

Ferreira, A.S., Silva, I.N., Oliveira, V.H., Cunha, R., Moreira, L.M., "Insights into the role of extracellular polysaccharides in Burkholderiaadaptation to different environments", Frontiers inCellular and Infection Microbiology, 1, article 16, 1-9, 2011.

Fialho, A.M., Chakrabarty, A.M., "Law-medicine interfacing: patenting of human genes and mutations", Recent Patents on DNA Gene Sequence, 5, 81-85, 2011.

Gil, F.N., Gonçalves, A.C., Jacinto, M.J., Becker, J.D., Viegas, C.A., "Transcriptional profiling in Saccharomyces cerevisiaerelevant for predicting alachlor mechanisms of toxicity", Environmental Toxicology and Chemistry, 30, 2506-2518, 2011.

Gonçalves, J.P., Francisco, A.P., Mira, N.P., Teixeira, M.C., Sá-Correia, I., Oliveira, A.L., Madeira, S.C., "TFRank: Network-based prioritization of regulatory associations underlying transcriptional responses", Bioinformatics, 27, 3149-57, 2011.

Lourenço, A.B., Ascenso, J.R., Sá-Correia, I., "Metabolic insights into the yeast response to propionic acid based on high resolution 1H NMR spectroscopy". Metabolomics, 7, 457-468, 2011.

Madeira, A., Santos, P.M., Coutinho, C.P., Pinto-de-Oliveira, A., Sá-Correia, I., "Quantitative proteomics (2-D-DIGE) reveals molecular strategies employed by Burkholderia cenocepaciato adapt to the airways of cystic fibrosis patients under antimicrobial therapy". PROTEOMICS, 11, 1313-1328, 2011.

Mendes, S., Farinha, A., Ramos, C.G., Leitão, J.H., Viegas, C.A., Martins, L.O., "Synergistic action of azoreductase and laccase leads to maximal decolourization and detoxification of model dye-containing wastewaters", Bioresource Technology, 102, 9852-9859, 2011.

Mil-Homens, D., Fialho, A.M., Trimeric autotransporter adhesins in members of the Burkholderia cepaciacomplex: a multifunctional family of proteins implicated in virulence Frontiers in Cellular and Infection Microbiology, 1, article 13, 2011.

Mira, N.P., Henriques S.F., Keller G., Matos R., Arraiano C., Teixeira M.C., Winge D.R. and Sá-Correia I., "Identification of a DNA-binding site for the transcription factor Haa1, required for Saccharomyces cerevisiaeresponse to acetic acid stress", Nucleic Acids Research, 16, 6896-907, 2011.

Mira, N.P., Madeira, A., Moreira, A.S., Coutinho, A.P., SÁ-Correia, I., "Genomic expression analysis reveals strategies of Burkholderia cenocepaciato adapt to the airways of cystic fibrosis patients and antimicrobial therapy", PLOS One, 6, e28831, 2011.

Monteiro, P.T., Dias, P.J., Ropers, D., Oliveira, A.L., Sá-Correia, I., Teixeira, M.C., Freitas, A.T., "Qualitative modeling and formal verification of the FLR1gene mancozeb response in Saccharomyces cerevisiae",IET Systems Biology, 5, 308-316, 2011.

Nadais H., Barbosa M., Capela I., Arroja L., Ramos C.G., Grilo A., Sousa S.A., Leitão J.H., "Enhancing Wastewater Degradation and Biogas Production by Intermittent Operation of UASB Reactors". Energy. 36, 2146-68, 2011.

Pereira, F.B., Guimarães, P.M.R., Gomes, D.G., Mira, N.P., Teixeira, M.C., Sá-Correia, I., Domingues, L., "Identification of candidate genes for yeast engineering to improve bioethanol production in Very-High-Gravity and lignocellulosic biomass industrial fermentations", Biotechnology for Biofuels, 4, 57, 2011.

Rocha, J., Popescu, A.O., Borges, P., Mil-Homens, D., Moreira, L.M., Sá-Correia, I., Fialho, A.M., Frazão, C., "Burkholderia cepaciaUDP-glucose dehydrogenase (BceC) structure and role of the Tyr10 in the final hydrolysis of UGDs thioester intermediate", JournalofBacteriology, 193, 3978-3987, 2011.

dos Santos, S.C., Sá-Correia, I., "A genome-wide screen identifies yeast genes required for protection against or enhanced cytotoxicity of the antimalarial drug quinine", Molecular Genetics and Genomics, 286(5-6), 333-326, 2011.

Silva, I.N., Ferreira, A.S., Becker, J.D., Zlosnik, J.E., Speert, D.P., He, J., Mil-Homens, D., Moreira, L.M., "Mucoid morphotype variation of Burkholderia multivoransduring chronic cystic fibrosis lung infection is correlated with changes in metabolism, motility, biofilm formation and virulence", Microbiology, 157, 3124-37, 2011.

Sousa, S.A., Ramos, C.G., Leitão, J.H., "Burkholderia cepaciacomplex: emerging multihost pathogens equiped with a wide range of virulence factors and determinants", Internation Journal of Microbiology, Article ID: 607575, 2011.

Teixeira, M.C., Cabrito, T.R., Hanif, Z.M., Vargas, R.C., Tenreiro, S., Sá-Correia, I., "Yeast response and tolerance to polyamine toxicity involving the drug:H+ antiporter Qdr3 and the transcription factors Yap1 and Gcn4". Microbiology, 157, 945-956, 2011.

Teixeira M.C., Mira N.P., Sá-Correia I., "A genome-wide perspective on the response and tolerance to food-relevant stresses in Saccharomyces cerevisiae". Current Opinion in Biotechnology, 22:150-156, 2011.

Teplitski, M., Leitão, J.H., Sela, S., "Microbial ecology and global health", Internation Journal of Microbiology, 2011: 564701, 2011.


Bernardes N., Seruca R., Chakrabarty A.M., Fialho A.M., 2009, "Microbial-based therapy of cancer: current progress and future prospects", Bioengineered Bugs, 1 (3), 178-190, 2010.

Chelinho S., Moreira-Santos M., Lima D., Silva C., Viana P., André S., Lopes I., Ribeiro R., Fialho A.M., Viegas C.A., Sousa J.P.. 2009. "Cleanup of atrazine contaminated soils: ecotoxicological study on the efficacy of a bioremediation tool with Pseudomonassp. ADP". Journal of Soils and Sediments, 10,568-578, 2010.

Dias P.J., Seret M.L., Goffeau A., Sá-Correia I., Baret P.V., "Evolution of the 12-spanner Drug:H+ Antiporter DHA1 family in hemiascomycetous yeasts". OMICS: a Journal of Integrative Biology, 14(6), 701-710, 2010.

Dias P.J., Teixeira M.C., Telo J.P., Sá-Correia I., "Insights into the mechanisms of toxicity and tolerance to the agricultural fungicide mancozeb in yeast, as suggested by a chemogenomic approach", OMICS: A Journal of Integrative Biology, 14(2), 211-227, 2010.

Ferreira A.S., Leitão J.H., Silva I.N., Pinheiro P.F., Sousa S.A., Ramos C.G., Moreira L.M., "Distribution of cepacian biosynthesis genes among environmental and clinical Burkholderiastrains and role of cepacian exopolysaccharide in resistance to stress conditions". Applied and Environmental Microbiology76, 441-450, 2010.

Kundu M., Thomas J., Fialho A.M., Kwan J.M., Moreira L., Mahfouz M., Das Gupta T.K., Chakrabarty A.M., "The anticancer activity of the N-terminal CARD-like domain of Arginine Deiminase (ADI) from Pseudomonas aeruginosa" Letters in Drug Design & Discovery, 6,403-412, 2010.

Leitão J.H., Sousa S.A., Ferreira A.S., Ramos C.G., Silva I.N., Moreira L.M., "Pathogenicity, virulence factors, and strategies to fight against Burkholderia cepaciacomplex pathogens and related species". Applied Microbiology and Biotechnology, 87, 31-40, 2010.

Madeira S., Teixeira M.C., Sá-Correia I., Oliveira A.L., "Identification of Regulatory Modules in Time Series Gene Expression Data using a Linear Time Biclustering Algorithm", IEEE/ACM Transactions on Computational Biology and Bioinformatics, 7: 153-165, 2010.

Mil-Homens D., Rocha E.P.C., Fialho A.M., "Genome-wide analysis of DNA repeats of DNA repeats in Burkholderia cenocepaciaJ2315 identifies a novel adhesin-like gene unique to epidemic-associated strains of ET-12 lineage", Microbiology, 156, 1084-1096, 2010.

Mira N.P., Becker J.D., Sá-Correia I., "Genomic expression program involving the Haa1p-regulon in Saccharomyces cerevisiaeresponse to acetic acid". OMICS: a Journal of Integrative Biology, 14(5), 587-601, 2010.

Mira, N.P., Palma, M., Guerreiro, J., Sá-Correia I., "Genome-wide identification of Saccharomyces cerevisiaegenes required for tolerance to acetic acid". Microbial Cell Factories, 9:79, 2010.

Mira N.P., Teixeira M.C., Sá-Correia I., "Adaptive response and tolerance to weak acids in Saccharomyces cerevisiae: a genome-wide view". OMICS: a Journal of Integrative Biology, 14(5), 525-540, 2010.

Ramos C.G., Grilo A.M., Sousa S.A., Barbosa M.L., Nadais H., Leitão J.H., "A new methodology combining PCR, cloning, and sequencing of clones discriminated by RFLP for the study of microbial populations: application to an UASB reactor sample". Applied Microbiology and Biotechnology85:801-806, 2010.

Ramos C.G., Sousa S.A., Grilo A.M., Eberl L., Leitão J.H., "The Burkholderia cenocepaciaK56-2 pleiotropic regulator Pbr, is required for stress resistance and virulence". MicrobialPathogenesis. 48(5), 168-177, 2010.

  Rocha J., Popescu A.O., Sá-Correia I., Fialho A.M., Frazão C., " Cloning, expression, purification, crystallization and preliminary crystallographic studies of BceC, a UDP-glucose dehydrogenase from Burkholderia cepacia IST408", Acta Crytallographica. Section F, Structural Biology and Crystallization Communications, 66, 269-271, 2010.

Rocha J., Granja A.T., Sá-Correia I., Fialho A.M., Frazão C., "Cloning, expression, crystallization and preliminary crystallographic studies of UgdG, and UDP-glucose dehydrogenase from Sphingomonas elodeaATCC 31461" Acta Crytallographica. Section F, Structural Biology and Crystallization Communications, 66, 69-72, 2010.

Roma-Rodrigues C., Santos P.M., Benndorf D., Rapp E., Sá-Correia I., "Response of Pseudomonas putida KT2440 to phenol at the level of membrane proteome", Journal of Proteomics, 73(8): 1461-1478, 2010.

Sá-Correia I., Teixeira M.C., "Two-dimensional Electrophoresis-based Expression Proteomics: a microbiologist's perspective". Expert Reviews in Proteomics, 7(6), 943-953, 2010.

Santos M.R., Cosme A.M., Becker J.D., Medeiros J.M.C., Mata M.F., Moreira L.M., "Absence of functional TolC protein causes increased stress response gene expression in Sinorhizobium meliloti". BMC Microbiology. 10(1): 180, 2010.

Sousa S.A., Ramos C.G., Moreira L.M., Leitão J.H., "The hfq gene is required for stress resistance and full virulence of Burkholderia cepaciato the nematode Caenorhabditis elegans". Microbiology156, 896-908, 2010.

Teixeira M.C., Dias P.J., Monteiro P.T., Sala A., Oliveira A.L., Freitas A.T., Sá-Correia I., "Refining current knowledge on the yeast FLR1regulatory network by combined experimental and computational approaches". Molecular Biosystems, 6(12), 2471 - 2481, 2010.

Teixeira M.C., Raposo L.R., Palma M., Sá-Correia I., "Identification of genes required for maximal tolerance to high-glucose concentrations, as those present in industrial alcoholic fermentation media, through a chemogenomics approach", OMICS: A Journal of Integrative Biology, 14(2), 201-210, 2010.

Velho S., Oliveira C., Paredes J., Sousa S., Leite M., Matos P., Milanezi F., Ribeiro A.S., Mendes N., Licastro D., Karhu A., Oliveira M.J., Ligtenberg M., Hamelin R., Carneiro F., Lindblom A., Peltomaki P., Castedo S., Schwartz Jr S., Jordan P., Aaltonen L.A., Hofstra R.M.W., Suriano G., E. Stupka, A.M. Fialho, R. Seruca, "Mized lineage kinase 3 gene mutations in mismatch repair deficient gastrointestinal tumours", Human Molecular Genetics, 19(4), 697-706, 2010.


Cabrito T.R., Teixeira M.C., Duarte A.A., Duque P., Sá-Correia I., "Heterologous expression of a Tpo1 homolog from Arabidopsis thalianaconfers resistance to the herbicide 2,4-D and other chemical stresses in yeast", Applied Microbiology and Biotechnology, 84, 927-936, 2009.

Coutinho C.P., Sá-Correia I., Lopes J.A., 2009, "Use of Fourier transform infrared spectroscopy and chemometrics to discriminate clinical isolates of bacteria of the Burkholderiacepaciacomplex from different species and ribopatterns" Analytical and Bioanalytical Chemistry, 394(8); 2161-2171, 2009.

Domingos S., Matos R.G., F.P. Reis, A.M. Fialho, A. Barbas, C.M. Arraiano, "Biochemical characterization of the RNaase II family of exoribonucleases from the human pathogens Salmonella typhimuriumand Streptococcuspneumoniae", Biochemistry48(50):11848-11857, 2009.

Gonçalves V.M.F., Reis A., Domingues M.R.M., Lopes-da-Silva J.A., Fialho A.M., Moreira L.M., Sá-Correia I., Coimbra M.A., "Structural analysis of gellans produced by Sphingomonaselodeastrains by electrospray tandem mass spectrometry", Carbohydrate Polymers,77, 10-19, 2009.

Holden M.T., Seth-Smith H.M., Crossman L.C., Sebaihia M., Bentley S.D., Cerdeño-Tárraga A.M., Thomson N.R., Bason N., Quail M.A., Sharp S., Cherevach I., Churcher C., Goodhead I., Hauser H., Holroyd N., Mungall K., Scott P., Walker D., White B., Rose H., Iversen P., Mil-Homens D., Rocha E.P., Fialho A.M., Baldwin A., Dowson C., Barrell B.G., Govan J.R., Vandamme P., Hart C.A., Mahenthiralingam E., Parkhill J. "The genome of BurkholderiacenocepaciaJ2315, an epidemic pathogen of cystic fibrosis patients." Journal of Bacteriology, 191(1):261-277, 2009.

Kwan J.M., Fialho A.M., Hong C.S., Kundu M., Das Gupta T.K., Chakrabarty A.M. (2009) "Bacterial Proteins as Potential Drugs in the Treatment of Leukemia", Leukemia Research, 33, 1392-1399, 2009.

Lima D., Viana P., André S., Chelinho S., Costa C., Ribeiro R., Sousa J.P., Fialho A.M., Viegas C.A., "Evaluating a bioremediation tool for atrazine contamination soies in open soil microcosmos: the effectiveness of bioaugmentation and biostimulation approaches". Chemosphere, 74, 187, 2009.

Mira N.P., Lourenço A., Fernandes A., Becker J., Sá-Correia I., "The RIM101pathway has a role in Saccharomyces cerevisiaeadaptive response and resistance to propionic acid and other weak acids", FEMS Yeast Research, 9, 202-216, 2009.

Pereira L., Coelho A.V., Viegas C.A., dos Santos M.M.C., Robalo M.P., Martins, L.O. "Enzymatic biotransformation of the azo dye Sudan Orange G with bacterial CotA-laccase", Journal ofBiotechnolology, 139, 68-77, 2009.

Sá-Correia I., dos Santos S.C., Teixeira M.C., Cabrito T.R., Mira N.P., "Drug:H+ antiporters in chemical stress response in yeast", Trends in Microbiology, 17, 22-31, 2009.

Pereira L., Coelho A.V., Viegas C.A., Ganachaud C., Lacazio G., Tron T., Robalo M.P., Martins L.O., "On the mechanism of biotransformation of the anthraquinonic dyce Acid Blue 62 by microbial laccase" Advances Synthesis & Catalysis, 351, 1857-1865, 2009.

dos Santos, S.C., Sá-Correia I., "Genome-wide identification of genes required for yeast growth under imatinib stress: vacuolar H +-ATPase function is an important target of this anticancer drug", OMICS: A Journal of Integrative Biology, 13: 185-198, 2009.

dos Santos S.C., Tenreiro S., Palma M., Becker J. and Sá-Correia I., "Transcriptomic profiling of the yeast response to quinine evidenced a glucose limitation response attributable to drug-induced inhibition of glucose uptake", Antimicrobial Agents and Chemotherapy, 53, 5213-5223, 2009.

Santos P.M., Sá-Correia I., "Adaptation to β-myrcene catabolism in Pseudomonassp. M1: an expression proteomics analysis", PROTEOMICS, 9, 5101-5111, 2009.

Santos P.M., Simões T., Sá-Correia I., "Insights into yeast adaptive response to the agricultural fungicide mancozeb: a toxicoproteomics approach", PROTEOMICS, 19, 657-670, 2009.

Teixeira M.C., Raposo L.R., Mira N.P., Lourenço A.B., and Sá-Correia I., "Genome-wide identification of genes required for maximal tolerance to ethanol in yeast: important role of FPS1" Applied and Environmental Microbiology., 75: 5761-5772, 2009.

Teixeira M.C., Santos P.M., Rodrigues C., Sá-Correia I., "Teaching Expression Proteomics: from the wet-lab to the laptop", Biochemistry and Molecular Biology Education, 37, 279-286, 2009.


Sousa S.A., Ramos C.G., Almeida L., Meirinhos-Soares L., Wopperer J., Schwager S., Eberl L., Leitão J.H., "Burkholderia cenocepaciaj2315 acyl carrier protein: a potential target for antimicrobials development", Microbial Pathogenesis, 45, 331-336, 2008.

Sousa S.A., Moreira L.M., Leitão J.H., "Functional analysis of the Burkholderia cenocepaciaJ2315 BceA protein with phosphomannose isomerase and GDP-D-mannose pyrophosphorylase activities", Applied Microbiology Biotechnology, 80, 1015-1022, 2008.

Cosme A.M., Becker A., Santos M.R., Sharypova L.A., Santos P.M., Moreira L.M. "The outer membrane protein TolC from Sinorhizobium melilotiaffects protein secretion, polysaccharide biosynthesis, antimicrobial resistance and symbiosis". Molecular Plant-Microbe Interactions, 21, 947-57, 2008.

Fialho A.M., Moreira L.M., Granja A.T., Popescu A.O., Hoffmann K., Sá-Correia I., "Occurrence, production and applications of gellan: current state and perspectives". Applied Microbiology Biotechnology, 79, 889-900, 2008.

Leitão J.H., Sousa S.A., Cunha M.V., Salgado M.J., Melo-Cristino J., Barreto M.C. and Sá-Correia I., "Variation of the antimicrobial susceptibility profiles of Burkholderia cepaciacomplex clonal isolates obtained from chronically infected cystic fibrosis patients: a five-year survey in the major Portuguese treatment center". European Journal of Clinical Microbiology & Infectious Diseases, 27, 1101-1111, 2008.

Monteiro P., Mendes N., Teixeira M.C., d'Orey S., Tenreiro S., Mira N.P., Pais H., Francisco A., Carvalho A., Lourenço A.R., Sá-Correia I., Oliveira A.L., Freitas A.T., "YEASTRACT-DISCOVERER: new tools to improve the analysis of transcriptional regulatory associations in Saccharomyces cerevisiae". Nucleic Acids Reseach, Database Issue, 36: D132-D136, 2008.

Naguleswaran A., Fialho A.M., Chaudhari A., Hong C.S., Chakrabarty A.M., Sullivan Jr. W.J., "Azurin-like protein blocks invasion of Toxoplasma gondiithrough potential interaction with parasite surface antigen SAG1", Antimicrobial Agents and Chemotherapy, 52, 402-408, 2008.

Teixeira M.C., Dias P.J., Simões T., Sá-Correia I., "Yeast adaptation to mancozeb involves the up-regulation of FLR1under the coordinate control of Yap1, Rpn4, Pdr3 and Yrr1", Biochemical Biophysical Research Communications, 367, 249-255, 2008.

Zlosnik J.E.A., Hird T., Fraenkel M., Moreira L.M., Henry D.A., Speert D.P., "Differential mucoid exopolysaccharide production by members of the Burkholderia cepaciacomplex", Journal of Clinical Microbiology,46, 1470-1473, 2008.


Aragão D., Fialho A.M., Marques A.R., Mitchell E.P., Sá-Correia I., Frazão C. "The complex of Sphingomonas elodeaATCC 31461 Glucose-1-phosphate uridylyltransferase with glucose-1-phosphate reveals a novel quaternary structure, unique among Nucleoside Diphosphate-sugar pyrophosphorylase members", Journal of Bacteriology, 189, 4520-4528, 2007.

Chaudhari A., Mahfouz M., Fialho A.M., Yamada T., Granja A.T., Zhu Y., Hashimoto W., Schlarb-Ridley B., Cho W., Das Gupta T., Chakrabarty A.M., "Cupredoxin-Cancer Interrelationship: Azurin Binding with EphB2,Interference of EphB2 Tyrosine Phosphorylation and Inhibition of Cancer Growth" Biochemistry, 46, 1799-1810, 2007.

Cunha M.V., Pinto-de-Oliveira A., Meirinhos-Soares L., Salgado M.J., Melo-Cristino J., Correia S., Barreto C., Sá-Correia I., "Exceptionally high representation of Burkholderia cepaciaamong B. cepacia complex isolates recovered from the Major Portuguese Cystic Fibrosis Center", Journal of Clinical Microbiology, 45, 1628-1633, 2007.

Ferreira A.S., Leitão J.H., Sousa S.A., Cosme A.M., Sá-Correia I., Moreira L.M. "Functional Analysis of Burkholderia cepacia bceDand bceFGenes Encoding a Phosphotyrosine Phosphatase and a Tyrosine Autokinase: Role in Exopolysaccharide Biosynthesis and Biofilm Formation", Applied and Environmental Microbiology, 73, 524-534, 2007.

Fialho A.M., Chakrabarty A.M., "Recent Patents on Bacterial Proteins as Potential Anticancer Agents" Recent Patents on Anti-Cancer Drug Discovery, 3, 224-234, 2007.

Fialho A.M., das Gupta T.K., Chakrabarty A.M., "Designing promiscuous drugs: Look at what nature made!", Letters in Drug Design & Discovery, 4, 40-43, 2007.

Fialho A.M., Stevens F.J., das Gupta T.K., Chakrabarty A.M., "Beyond host-pathogen interactions: microbial defense strategy in the host environmental", Current Opinion in Biotechnology, 18, 279-286, 2007.

Granja A.T., Popescu A., Marques A.R., Sá-Correia I., Fialho A.M., "Biochemical characterization and phylogenetic analysis of UDP-glucose dehydrogenase from the gellan gum producer Sphingomonas elodeaATCC 31461" Applied Microbiology and Biotechnology, 76, 1319-1327, 2007.

Santos P.M., Roma V., Benndorf D., von Bergen M., Harms H., Sá-Correia I., "Mechanistic insights into the global response to phenol in the phenol-biodegrading strain Pseudomonassp. M1, revealed by quantitative proteomics", OMICS: A Journal of Integrative Biology,11, 233-251, 2007.

Santos P.M., Sá-Correia I., "Characterization of the unique organization and co-regulation of a gene cluster required for phenol and benzene catabolism in Pseudomonassp. M1". Journal of Biotechnology, 131, 371-378, 2007.

Sousa S.A., Moreira L.M., Wopperer J., Eberl L., Sá-Correia I., Leitão J.H., "The Burkholderia cepaciabceA gene encodes a protein with phosphomannose isomerase and GDP-D-mannose pyrophosphorylase activities", Biochemical and Biophysical Research Communications, 353, 200-206, 2007.

Sousa S.A., Ulrich M., Bragonzi A., Burke M., Worlitzch D., Leitão J.H., Meisner C., Eberl L., Sá-Correia I., Döring G., "Virulence of Burkholderia cepaciacomplex strain in gp91 phox-/-mice", Cellular Microbiology, 9, 2817-2825, 2007.

Teixeira M.C., Duque P., Sá-Correia I., "Environmental Genomics: mechanistic insights into toxicity of and resistance to the herbicide 2,4-D", Trends in Biotechnology, 25: 363-370, 2007.

Vargas R.C., García-Salcedo R., Tenreiro S., Teixeira M.C., Fernandes A.R., Ramos J. and Sá-Correia I., "Saccharomyces cerevisiaemultidrug resistance transporter Qdr2 is implicated in potassium uptake, providing a physiological advantage to quinidine-stressed cells", Eukaryotic Cell, 6, 134-142, 2007.


Alenquer M., Tenreiro S., Sá-Correia I., Adaptive response to the antimalarial drug artesunate in yeast involves Pdr1p/Pdr3p-mediated transcriptional activation of the resistance determinants TPO1and PDR5. FEMS Yeast Research, 6, 1130-1139, 2006.

Amblar M., Barbas A., Fialho A.M., Arraiano C.M., "Characterization of the functional domains of Escherichia coliRNase II", Journal of Molecular Biology, 360, 921-933, 2006.

Aragão D., Marques A.R., Frazão C., Enguita F.J., Carrondo M.A., Fialho A.M., Sá-Correia I., E.P. Mitchell, "Cloning, expression, purification, crystallization and preliminary structure determination of glucose-1-phosphate uridylytransferase (UgpG) from Sphingomonas elodeaATCC 31461 bound to glucose-1-phosphate",Acta Crystallographica, F62, 930-934, 2006.

Chaudhari A., Fialho A.M., Ratner D., Gupta P., Hong C.S., Kahali S., Yamada T., Haldar K., Murphy S., Cho W., Chauhan V.S., das Gupta T.K., Chakrabarty A.M., "Azurin, Plasmodium falciparumand HIV/AIDS: Inhibition of parasitic and viral growth by azurin", Cell Cycle, 5, 1642-1648, 2006.

Hong C.S., Yamada T., Hashimoto W., Fialho A.M., das Gupta T.K., Chakrabarty A.M., "Disrupting the entry barrier and attacking brain tumors: The role of the Neisseria H.8 epitope and the Laz protein", Cell Cycle, 5, 1633-1641, 2006.

Mendes N.D., Casimiro A.C., Santos P.M., Sá-Correia I., Oliveira A.L., Freitas A.T., "MUSA: A parameter free algorithm for the identification of biologically significant motifs", Bioinformatics, 22, 2996-3002,2006.

Simões T., Mira N.P., Fernandes A.R., Sá-Correia I., "The SPI1 gene, encoding a glycosylphosphatidylinositol (GPI)-anchored cell wall protein, plays a prominent role in the development of yeast resistance to lipophilic weak acids food preservatives", Applied and Environmental Microbiology, 72, 7168-7175, 2006.

Teixeira M.C., Fernandes A.R., Mira N.P., Becker J.D., Sá-Correia I., "Early transcriptional response of Saccharomyces cerevisiaeto stress imposed by the herbicide 2,4-dichlorophenoxyacetic acid", FEMS Yeast Research, 6, 230-248, 2006.

Teixeira M.C., Monteiro P., Jain P., Tenreiro S., Fernandes A.R., Mira N.P., Alenquer M., Freitas A.T., Oliveira A.L., Sá-Correia I., "The YEASTRACT database: a tool for the analysis of transcriptional regulatory associations in Saccharomyces cerevisiae", Nucleic Acids Research, Database Issue, 34, D446-D451, 2006.


Fernandes A.R., Mira N.P., Vargas R.C., Canelhas I., Sá-Correia I., "Saccharomyces cerevisiaeadaptation to weak acids involves the transcription factor Haa1p and of Haa1p-regulated genes", Biochemical and Biophysical Research Communications, 337, 95-103, 2005.

Hiraoka Y., Granja A.T., Fialho A.M., Schlarb-Ridley B., Das Gupta T.K., Chakrabarty A.M., Yamada T., "Human cytochrome c enters murine J7774 cells and causes G1 and G2/M cell cycle arrest and induction of apoptosis" Biochemical and Biophysical Research Communications, 338, 1284-1290, 2005.

Silva E., Marques A.R., Fialho A.M., Granja A.T., Sá-Correia I., "Proteins Encoded by Sphingomonas elodeaATCC 31461 rmlA and ugpG genes, involved in gellan gum biosynthesis, exhibit both dTDP- and UDP-Glucose pyrophosphorylase activities", Applied and Environmental Microbiology, 71, 4703-4712, 2005.

Strino F., Nahmany A., Rosen J., Kemp G.J.L., Sá-Correia I., Nyholm P-G, "Conformation of the exo-polysaccharice fo Burkholderia cepaciapredicted with molecular mechanics (MM3) using genetic algorithm search", Carbohydrate Research, 340, 1019-1024, 2005.

Teixeira M.C., Santos P.M., Fernandes A.R., Sá-Correia I., "A proteome analysis of yeast response to the herbicide 2,4-dicholorophenoxyacetic acid", Proteomics,5, 1889-1901, 2005.

Tenreiro S., Vargas R.C., Teixeira M.C., Magnani C., Sá-Correia I., "The yeast multidrug transporter Qdr3 (Ybr043c): localization and role as a determinat of resistance to quinidine, barban, cisplatin and bleomycin", Biochemical and Biophysical Research Communications, 327, 952-959, 2005.

Videira P.A., Garcia A.P., Sá-Correia I., "Functional and topological analysis of Burkholderia cenocepaciapriming glucosyltransferase BceB, involved in the biosynthesis of the cepacian exopolysaccharide, Journal of Bacteriology, 187, 5013-5018, 2005.

Viegas C.A., Cabral M.G., Teixeira M.C., Neumann G., Heipieper H.J., Sá-Correia I., Yeast adaptation to 2,4-dichlorophenoxyacetic acid involves increased membrane fatty acid saturation degree and decreased OLE1transcription, Biochemical and Biophysical Research Communications, 330: 271-278, 2005.

Yamada T., Fialho, Punj V., Bratescu L., Das Gupta T., Chakrabarty A.M., "Internalization of bacterial redox protein azurin in mammalian cells: entry domain and specificity", Cellular Microbiology, 7: 1418-1431, 2005.


Cabral M.G., Sá-Correia I., Viegas C.A., "Adaptative responses in yeast to the herbicide 2-methyl-4-chlorophenoxyacetic acid at the level of intracellular pH homeostasis", Journal of Applied Microbiology, 96, 603-612, 2004.

Cunha M.V., Sousa S.A., Leitão J.H., Moreira L.M., Videira P.A., Sá-Correia I., "Studies on the involvement of the exopolysaccharide produced by cystic fibrosis-associated isolates of the Burkholderia cepaciacomplex in biofilm formation and in persistence of respiratory infections", Journal of Clinical Microbiology, 42, 3052-3058, 2004.

Moreira L.M., Hoffmann K., Albano H., Becker A., Niehaus K. and Sá-Correia I., "The gellan gum biosynthetic genes gelC and gelE encode two separate polypeptides homologous to the activator and the kinase domains of tyrosine autokinases", Journal of Molecular Microbiology and Biotechnology, 8, 43-57, 2004.

Papaefthimiou C., Cabral M.G., Mixailidou C., Viegas C.A., Sá-Correia I., Theophilidis G., "Comparison of two screening bioassays, based on the frog sciatic nerve and yeast cells, for the assessment of herbicide toxicity", Environmental Toxicology and Chemistry, 23, 1211-1218, 2004.

Santos P.M., Benndorf D., Sá-Correia I., "Insights in Pseudomonas putidaKT2440 response to phenol-induced stress by quantitative proteomics" Proteomics, 4, 2640-2652, 2004.

Silva E., Fialho A.M., Sá-Correia I., Burns R.G., Shaw L.J., "Combined bioaugmentation and biostimulation to clean-up soil contaminated with high concentrations of atrazine", Environmental Science and Technology, 38, 632-637, 2004.

Teixeira M.C., Telo J.P., Duarte N.F., Sá-Correia I., "The herbicide 2,4-dichlorophenoxyacetic acid induces the generation of free-radicals and associated oxidative stress responses in yeast", Biochemical and Biophysical Research Communications, 324, 1101-1107, 2004.

Vargas R.C., Tenreiro S., Teixeira M.C., Fernandes A.R., Sá-Correia I., "Saccharomyces cerevisiaemultidrug transport Qdr2p (Yil121wp): localization and function as a quinidine resistance determinant", Antimicrobial Agents and Chemotherapy, 48, 2531-2537, 2004.

Velasco I., Tenreiro S., Calderon I.L., and André B." Saccharomyces cerevisiaeAqr1 is an internal-membrane transporter involved in excretion of amino acids". Eukaryotic Cell, 3, 1492-1503, 2004.


Cabral M.G., Viegas C.A., Teixeira M.C. and Sá-Correia I., "Toxicity of chlorinated phenoxyacetic acid herbicides in the experimental eukaryotic model Saccharomyces cerevisiae: role of pH and of growth phase and size of the yeast cell population", Chemosphere, 51, 47-54, 2003.

Cunha M.V., Leitão J.H., Mahenthiralingam E., Vandamme P., Lito L., Barreto C., Salgado M.J., Sá-Correia I., "Molecular analysis of Burkholderia cepaciacomplex isolates from a Portuguese cystic fibrosis center: a seven-year study", Journal of Clinical Microbiology, 41, 4113-4120, 2003.

Fernandes A.R., Sá-Correia I. "Transcription patterns of PMA1and PMA2genes and activity of plasma membrane H +-ATPase in Saccharomyces cerevisiaeduring diauxic growth and stationary phase", Yeast, 20, 207-219, 2003.

Fernandes, A.R., Durão P.J., Santos P.M., Sá-Correia I., "Activation and significance of vacuolar H +-ATPase in Saccharomyces cerevisiaeadaptation and resistance to the herbicide 2,4-dichlorophenoxyacetic acid (2,4-D)", Biochemical and Biophysical Research Communications, 312, 1317-1324, 2003.

Kabelitz N., Santos P.M., Heipieper H.J., "Effect of aliphatic alcohols on growth and degree of saturation of membrane lipids in Acinetobacter calcoaceticus", FEMS Microbiology Letters, 220, 223-227, 2003.

Marques A.R., Coutinho P.M., Videira P.A., Fialho A.M., Sá-Correia I., "Sphingomonas paucimobilisbeta-glucosidase Bgl1: a member of a new bacterial subfamily in family 1 of glycoside hydrolases", Biochemical Journal, 370,793-804, 2003.

Marques A.R., Ferreira P.B., Sá-Correia I., Fialho A.M., "Characterization of the ugpG gene encoding a UDP-glucose pyrophosphorylase from the gellan gum producer Sphingomonas paucimobilisATCC 31461", Molecular Genetics and Genomics, 268, 816-824, 2003.

Moreira L.M., Videira P.A., Sousa S.A., Leitão J.H., Cunha M.V., Sá-Correia I., "Identification and physical organization of the gene cluster involved in the biosynthesis of Burkholderia cepaciacomplex exopolysaccharide", Biochemical and Biophysical Research Communications, 312, 323-333, 2003.

Simões T., Teixeira M.C., Fernandes A.R., Sá-Correia I., "Adaptation of Saccharomyces cerevisiaeto the herbicide 2,4-dichlorophenoxyacetic acid, mediated by Msn2p- and Msn4p-regulated genes: important role of SPI1", Applied and Environmental Microbiology, 69, 4019-4028, 2003.

Sist P., Cescutti P., Sveerlavaj S., Urbani R., Leitão J.H., Sá-Correia I., Rizzo R., "Macromolecular and solution properties of Cepacian: the exopolysaccharide produced by a strain ofBurkholderia cepaciaisolated from a cystic fibrosis patient", Carbohydrate Research, 338, 1861-1867, 2003.

Tavares I.M., Leitão J.H., Sá-Correia I., "Chromosomal organization and transcription analysis of genes in the vicinity of Pseudomonas aeruginosa glmMgene encoding phosphoglucosamine mutase", Biochemical and Biophysical Research Communications, 302, 363-371, 2003.

Videira P.A., Fialho A.M., Marques A.R., Coutinho P.M., Sá-Correia, I, "Cloning and sequence analysis of the ces 10 gene encoding a Sphingomonas paucimobilisesterase", Applied Microbiology and Biotechnology, 61, 517-522, 2003.


Felder T., Bogengruber E., Tenreiro S., Ellinger A., Sá-Correia I., Briza P., "Dtr1p, a multidrug resistance transporter of the major facilitator superfamily, plays an essential role in spore wall maturation in Saccharomyces cerevisiae", Eukaryotic Cell, 1, 799-810, 2002.

Sá-Correia I., Fialho A. M., Videira P.A., Moreira L. M., Marques A. R., Albano H., "Gellan gum biosynthesis in Sphingomonas paucimobilisATCC 31461: genes, enzymes and exopolysaccharide production engineering", Journal of Industrial Microbiology and Biotechnology, 29, 170-176, 2002.

Sá-Correia I., Tenreiro S., "The multidrug resistance transporters of the major facilitator superfamily, six years after disclosure of Saccharomyces cerevisiaegenome sequence", Journal of Biotechnology, 98, 215-226, 2002.

Santanta F.M.C., Pinto T., Fialho A.M., Sá-Correia I., Empis J., "Bacterial removal of quinolizidine alkaloids and other carbon sources from a Lupinus albusaqueous extract", Journal of Agricultural and Food Chemistry, 50, 2318-2323, 2002.

Teixeira M.C. Sá-Correia I., "Saccharomyces cerevisiaeresistance to chlorinated phenoxyacetic acid herbicides involves Pdr1p-mediated transcriptional activation of TPO1and PDR5genes", Biochemical Biophysical Research Communications, 292, 530-537, 2002.

Tenreiro S., Nunes P.A., Viegas C.A., Neves M.S., Teixeira M.C, Cabral M.G., Sá-Correia I., " AQR1gene (ORF YNL065w) encodes a plasma membrane transporter of the Major Facilitator Superfamily that confers Resistance to Short-chain Monocarboxylic Acids and Quinidine in Saccharomyces cerevisiae", Biochemical and Biophysical Research Communications,292, 741-748, 2002.


Becker J.D., Moreira L.M., Kapp D., Frosch S.C., Pühler A., Perlick A.M., The nodulin VfENOD18 is an ATP-binding protein in infected cells of Vicia fabaL. nodules, Plant Molecular Biology, 47, 749-759, 2001.

Cabral M.G., Viegas C.A., Sá-Correia I., Mechanisms underlying the acquisition of resistance to octanoic-acid-induced-death following exposure of Saccharomyces cerevisiaeto mild stress imposed by octanoic acid or ethanol, Archives of Microbiology, 175, 301-307, 2001.

Fernandes A. R. and Sá-Correia I., The activity of plasma membrane H +-ATPase is strongly stimulated during Saccharomyces cerevisiaeadaptation to growth under higher copper stress accompanying intracellular acidification, Yeast, 18, 511-521, 2001.

Fort S., Coutinho P.M., Schülein M., Nardin R., Cottaz S., Driguez H., The rational design of an iminosugar inhibitor able to mimic substrate distortion occurring during retaining-cellulase hydrolysis. Tetrahedron Letters42, 3443-3446, 2001.

Henrissat B. Coutinho P., Classification of glycoside hydrolases and glycosyltransferases from hyperthermophiles, Methods in Enzymology, 330, 183-201, 2001.

Henrissat B., Coutinho P.M., Davies G.J., A census of carbohydrate-active enzymes in the genome of Arabidopsis thaliana. Plant Molecular Biology, 47, 55-72, 2001.

Nunes P.A., Tenreiro S., Sá-Correia I., Resistance and adaptation to quinidine in Saccharomyces cerevisiae: role of QDR1gene (ORF YIL120w), encoding a plasma membrane transporter of the Major Facilitator Superfamily required for multidrug resistance", Antimicrobial Agents and Chemotherapy, 45, 1528-1534, 2001.

Tenreiro S., Fernandes A.R., Sá-Correia I., Transcriptional activation of FLR1gene during Saccharomyces cerevisiaeadaptation to growth with benomyl: role of Yap1 and Pdr3p, Biochemical and Biophysical Research Communications, 280, 216-222, 2001.

Videira P.A., Fialho A.M., Geremia R.A., Breton C., Sá-Correia I., Biochemical characterisation of beta-1-4-glucuronosyltransferase GelK in the gellan gum producing strain Sphingomonas paucimobilisATCC31461, Biochemical Journal, 358, 457-464, 2001.


Abdallah B.S., Simões T., Fernandes A.R., Strauss J., Seiboth B., Sá-Correia I. and Kubicek C.P., Glucose does not activate the plasma-membrane-bound-H+-ATPase but affects pmaA transcript abundance in Aspergillus nidulans, Archives of Microbiology, 174, 340-345, 2000.

Cescutti P., Bosco M., Picotti F., Impalloment G., Leitão J.H., Richau J. and Sá-Correia I., Structural study of the exopolysaccharide produced by a clinical isolate of Burkholderia cepacia, Biochemical and Biophysical Research Communications, 273, 1088-1094, 2000.

Fernandes A.R., Prieto M. and Sá-Correia I., Modification of plasma membrane lipid order and H +-ATPase activity as part of the response of Saccharomyces cerevisiaeto cultivation under mild and high copper stress, Archives of Microbiology, 173, 262-268, 2000.

Liu H.L., Doleyres Y., Coutinho P.M., Ford C., Reilly P.J., Replacement and deletion mutations in the catalytic domain and belt region of Aspergillus awamoriglucoamylase to enhance thermostability, Protein Engineering, 13(9), 655-659, 2000.

Moreira L. M., Becker J. D., Pähler A., and Becker A., The Sinorhizobium melilotiExpE1 protein secreted by a type I secretion system involving ExpD1 and ExpD2 is required for biosynthesis or secretion of the exopolysaccharide galactoglucan. Microbiology, 146, 2237-2248, 2000.

Richau J., Leitão J.H., Correia M., Lito L., Salgado M.J., Barreto C., Cescutti P. and Sá-Correia I. Sá-Correia, Molecular typing and exopolysaccharide biosynthesis of Burkholderia cepaciaisolates from a Portuguese Cystic Fibrosis Center, Journal of Clinical Microbiology, 38, 1651-1655, 2000.

Richau J.A., Leitão J.H. and Sá-Correia I., Enzymes leading to the nucleotide sugar precursors for exopolysaccharide synthesis in Burkholderia cepacia, Biochemical and Biophysical Research Communications, 276, 71-76, 2000.

Tavares I.M., Jolly L., Pompeo F., Leitão J.H., Fialho A.M., Sá-Correia I. and Mengin-Lecreulx D., Identification of the Pseudomonas aeruginosaglmM gene encoding phosphoglucosamine mutase, Journal of Bacteriology, 182, 4453-4457, 2000.

Tenreiro S., Rosa P.C., Viegas C.A. and Sá-Correia I., Expression of AZR1gene (ORF YGR224w), encoding a plasma membrane transporter of the Major Facilitator Superfamily, is required for adaptation to acetic acid and resistance to azoles in Saccharomyces cerevisiae, Yeast, 16, 1469-1481, 2000.

Videira P., Cortes L.L., Fialho A.M. and Sá-Correia I., Identification of the pgmGgene, encoding a bifunctional protein with phosphoglucomutase and phosphomannomutase activities, in the gellan gum producing strain Sphingomonas paucimobilisATCC 31461, Applied and Environmental Microbiology, 66, 2252-2258, 2000.


Bayer E.A., Coutinho P.M. and Henrissat B., Cellulosome-like sequences in Archaeoglobus fulgidus: an enigmatic vestige of cohesin and dockerin domains, FEBS Letters, 463, 277-280, 1999.

Brôco N., Tenreiro S., Viegas C.A. and Sá-Correia I., FLR1gene (ORF YBR008c) is required for benomyl and methotrexate resistance in Saccharomyces cerevisiaeand its benomyl-induced-expression is dependent on Pdr3 transcriptional regulator, Yeast, 15, 1595-1608,1999.

Chambel A., Viegas C.A. and Sá-Correia I., Effect of cinnamic acid on the growth and on plasma membrane H +-ATPase activity of Saccharomyces cerevisiae, International Journal of Food Microbiology, 50, 173-179, 1999.

Fernandes A. R. and Sá-Correia I., "Comparative effects of Saccharomyces cerevisiaecultivation under copper stress on the activity and kinetic parameters of plasma-membrane-bound H +-ATPases PMA1and PMA2", Archives of Microbiology, 171, pp 273-278, 1999.

Fialho A.M., Martins L.O., Donval M-L., Leitão J.H., Ridout M.J., Jay A.J., Morris V.J. and Sá-Correia I., Structures and properties of gellan polymers produced by Sphingomonas paucimobilisATCC 31461 from lactose compared with those produced from glucose and from cheese whey, Applied and Environmental Microbiology, 65, 2485-2491, 1999.

Tavares I.M., Leitão J.H., Fialho A.M. and Sá-Correia I., Pattern of changes in the activity of enzymes of GDP-D-mannuronic acid synthesis and in the level of transcription of algA, algC and algD genes accompanying the loss and emergence of mucoidy in Pseudomonas aeruginosa, Research in Microbiology, 150, 105-116, 1999.


Carmelo V., Santos R., Viegas C.A. and Sá-Correia I., Modification of Saccharomyces cerevisiaethermotolerance following rapid exposure to acid stress, International Journal of Food Microbiology, 42, 225-230, 1998.

Fernandes A.R., Peixoto F.P. and Sá-Correia I., Activation of the H+-ATPase in the plasma membrane of cells of Saccharomyces cerevisiaegrown under mild copper stress, Archives of Microbiology, 171, 6-12, 1998.

Jay A.J., Colquhoun I.J., Ridout M.J., Brownsey G.J., Morris V.J., Fialho A.M., Leitão J.H. and Sá-Correia I., Analysis of structure and function of gellans with different substitution patterns, Carbohydrate Polymers, 35, 179-188, 1998.

Lupi F.M., Fernandes H.M.L. and Sá-Correia I., Increase of copper toxicity to growth of Chlorella vulgariswith increase of light intensity, Microbial Ecology, 35, 193-198, 1998.

Monteiro G.A. and Sá-Correia I., In vivo activation of yeast plasma membrane H+-ATPase by ethanol: effect on the kinetic parameters and involvement of the carboxyl-terminus regulatory domain, Biochimica et Biophysica Acta, 1370, 310-316, 1998.

Viegas C.A., Almeida P.F., Cavaco M. and Sá-Correia I., The H+-ATPase in the plasma membrane of Saccharomyces cerevisiaeis activated during growth latency in octanoic acid-supplemented medium following the decrease in intracellular pH and cell viability, Applied and Environmental Microbiology, 64, 779-783, 1998.


Carmelo V. and Sá-Correia I., HSP26gene transcription is strongly induced during Saccharomyces cerevisiaegrowth at low pH, FEMS Microbiology Letters, 149, 85-88, 1997.

Carmelo V., Santos H., and Sá-Correia I., Effect of extracellular acidification on the activity of plasma membrane ATPase and on the cytosolic and vacuolar pH of Saccharomyces cerevisiae, Biochimica Biophysica Acta, 1325, 63-70, 1997.

Leitão J.H. and Sá-Correia I., Effect of growth-inhibitory concentrations of copper on alginate biosynthesis in highly mucoid Pseudomonas aeruginosa, Microbiology, 1 43, 481-488, 1997.

Leitão J.H. and Sá-Correia I., Oxygen-dependent up-regulation of transcription of alginate genes, algA, algC and algD, in Pseudomonas aeruginosa, Research in Microbiology, 148, 37-43, 1997.

Moreira L. M., da Costa M. S. and Sá-Correia I., Comparative genomic analysis of isolates belonging to the six species of the genus Thermususing pulsed-field gel electrophoresis and ribotyping, Archives of Microbiology,168, 92-101, 1997.

Moreira L.M. and Sá-Correia I., Megaplasmids in Thermus oshimaiisolates from two widely separated geographical areas: restriction fragment profiling and DNA homology, Archives of Microbiology, 168, 473-479, 1997.

Richau J.A., Choquenet D., Fialho A.M. and Sá-Correia I., Emergence of Cu++-tolerant mutants defective in gellan synthesis in Cu++-stressed cultures of Sphingomonas paucimobilis, Research in Microbiology, 148, 251-261, 1997.

Richau J.A., Choquenet D., Fialho A.M., Moreira L.M. and Sá-Correia I., The Biosynthesis of the Exopolysaccharide Gellan Results in the Decrease of Sphingomonas paucimobilisTolerance to Copper (Cu 2+), Enzyme and Microbial Technology, 20, 510-515, 1997.

Viegas C.A. and Sá-Correia I., Effects of low temperatures (9-33ºC) and pH (3.3-5.7) in the loss of Saccharomyces cerevisiaeviability by combining lethal concentrations of ethanol with octanoic and decanoic acids, International Journal of Food Microbiology, 34, 267-277, 1997.


Carmelo V., Bogaerts P. and Sá-Correia I., Activity of Plasma Membrane H +-ATPase and Expression of PMA1and PMA2Genes in Saccharomyces cerevisiaeCells Grown at Optimal and Low pH, Archives of Microbiology, 166, 315-320, 1996.

Leitão J.H., Alvim T. and Sá-Correia I., Ribotyping of Pseudomonas aeruginosaIsolates from Patients and Water Springs and Genome Fingerprinting of Variants concerning Mucoidy, FEMS Immunology and Medical Microbiology, 13, 287-292, 1996.

Martins L.O., Fialho A.M., Rodrigues P.L. and Sá-Correia I., Gellan Gum Production and Activity of Biosynthetic Enzymes in Sphingomonas paucimobilisMucoid and Non-mucoid Variants, Biotechnology and Applied Biochemistry, 24, 47-54, 1996.

Moreira L.M., Nobre M.F., Sá-Correia I. and da Costa M.S., Genomic typing and fatty acid composition of Rhodothermus marinus, Systematic and Applied Microbiology, 19, 83-90, 1996.

Rosa M.F. and Sá-Correia I., Intracellular Acidification does not account for Inhibition of Saccharomyces cerevisiaeGrowth in the Presence of Ethanol, FEMS Microbiology Letters, 135, 271-274, 1996.

Santana F.M.C., Fialho A.M., Sá-Correia I. and Empis J.M.A., Isolation of bacterial strains capable of using lupanine, the predominant quinolizidine alkaloid in white lupin, as sole carbon and energy source", Journal of Industrial Microbiology, 17, 110-115, 1996.


Carmelo V., Bogaerts P. and Sá-Correia I., Effects of extracellular acidification on the activity of yeast plasma membrane H +-ATPase and expression of PMA1and PMA2genes, Yeast(special issue), 11, S426, 1995.

Leitão J.H. and Sá-Correia I., Growth-phase-dependent Alginate Synthesis, Biosynthetic Enzymes and Expression of Alginate Genes in Pseudomonas aeruginosa, Archives of Microbiology, 163, 217-222, 1995.

Moreira L.M., da Costa M.S. and Sá-Correia I., Plasmid RFLP Profiling and DNA Homology in Thermus isolated from Hot Spring of Different Geographical Areas, Archives of Microbiology, 164, 7-15, 1995.

Rosa M.F., Viegas C.A. and Sá-Correia I., Toxicity of ethanol and octanoic acid and the intracellular acidification in Saccharomyces cerevisiae, Yeast(special issue), 11, S592, 1995.

Viegas C.A. and Sá-Correia I., Toxicity of Octanoic Acid in Saccharomyces cerevisiaeat Temperatures between 8.5 and 30ºC, Enzyme and Microbial Technology, 17, 826-831, 1995.

Viegas C.A., Sebastião P.B., Nunes A.G. and Sá-Correia I., Activation of Plasma Membrane H +-ATPase and Expression of PMA1and PMA2Genes in Cells of Saccharomyces cerevisiaeGrown at Supra-optimal Temperatures, Applied and Environmental Microbiology, 61, 1904-1909, 1995.


Lupi F.M., Fernandes H.M.L., Tomé M.M., Sá-Correia I. and Novais J.M., Influence of the Nitrogen Source and Photoperiod on Exopolysaccharide Synthesis by the Microalga Botryococcus braunii, Enzyme and Microbial Technology, 16, 546-550, 1994.

Martins L.O. and Sá-Correia I., Temperature Profiles of Gellan Gum Synthesis and Activities of Biosynthetic Enzymes, Biotechnology and Applied Biochemistry, 20, 385-395, 1994.

Monteiro G.A., Supply P., Goffeau A. and Sá-Correia I., The in vivo Activation of Saccharomyces cerevisiaePlasma Membrane H+-ATPase by Ethanol Depends on the Expression of the PMA1Gene but not of PMA2Gene, Yeast, 10, 1439-1446, 1994.

Rosa M.F. and Sá-Correia I., Limitations to the Use of Extracellular Acidification for the Assessment of Plasma Membrane H +-ATPase Activity and Ethanol Tolerance in Yeasts, Enzyme and Microbial Technology, 16, 808-812, 1994.

Viegas C.A., Supply P., Capieux E., van Dyck L., Goffeau A. and Sá-Correia I., Regulation of the Expression of the H +-ATPase Genes PMA1and PMA2during Growth and Effects of Octanoic Acid in Saccharomyces cerevisiae, Biochimica Biophysica Acta, (Gene Structure & Expression) 1217, 74-80, 1994.