1. Nunes J, Charneira C, Nunes C, Gouveia-Fernandes S, Serpa J, Morello J*, Antunes AMM*. A Metabolomics-Inspired Strategy for the Identification of Protein Covalent Modifications. Front. Chem. 2019, 7, 532. https://doi.org/10.3389/fchem.2019.00532
2. de Conti A, Tryndyak V, VonTungeln LS, Churchwell MI, Beland FA, Antunes AMM*, Pogribny IP*. Genotoxic and Epigenotoxic Alterations in the Lung and Liver of Mice Induced by Acrylamide: A 28 Day Drinking Water Study. Chem Res Toxicol. 2019, 26, 869-877. https://doi.org/10.1021/acs.chemrestox.9b00020.
3. Marinho AT, Miranda JP, Caixas U, Charneira C, Gonçalves-Dias C, Marques MM, Monteiro EC, Antunes AMM*, Pereira SA*. Singularities of nevirapine metabolism: from sex-dependent differences to idiosyncratic toxicity. Drug Metab Rev 2019, 1-31. https://doi.org/10.1080/03602532.2019.1577891.
4. Nunes J, Charneira C, Morello J, Rodrigues J, Pereira SA, Antunes AMM.* Mass SpectrometryBased Methodologies for Targeted and Untargeted Identification of Protein Covalent Adducts (Adductomics): Current Status and Challenges. High Throughput. 2019, 8. pii: E9. https://doi.org/10.3390/ht8020009.
5. Gonçalves-Dias C, Morello J, Semedo V, Correia MJ, Coelho NR, Monteiro EC, Antunes AMM, Pereira SA*. The mercapturomic profile of health and non-communicable diseases. High Throughput. 2019, 8, pii: E10. https://doi.org/10.3390/ht8020010.
6. André V, Ferreira da Silva AR, Fernandes A, Frade R, Garcia C, Rijo P, Antunes AMM, Rocha J, Duarte MT. Mg- and Mn-MOFs Boost the Antibiotic Activity of Nalidixic Acid. CS Appl. Bio Mater. 2019, 26, 2347-2354. https://doi.org/10.1021/acsabm.9b00046.
7. Soto K, Campos P, Manso R, Antunes AMM, Morello J, Perazella MA. Severe AKI and double tubulopathy due to dual toxicity caused by combination antiretroviral therapy. Kidney International Reports, 2019. https://doi.org/10.1016/j.ekir.2018.11.014.
8. Gonçalves-Dias C, Morello J, Correira MJ, Coelho NR, Antunes AMM, Macedo MP, Monteiro EC, Soto K, Pereira SA. Mercapturate pathway in the tubulocentric perspective of diabetic kidney disease. 2019, Nephron, https://doi.org/10.1159/000494390.
9. Martins IL, Nunes J, Charneira C, Morello J, Pereira SA, Telo JP, Marques MM, Antunes AMM*. The first-line antiepileptic drug carbamazepine: Reaction with biologically relevant free radicals. Free Radic Biol Med. 2018, 129, 559-568. http://doi.org/10.1016/j.freeradbiomed.2018.10.408
10. Godinho ALA, Martins IL, Nunes J, Charneira C, Grilo J, Silva DM, Pereira SA, Soto K, Oliveira MC, Marques MM, Jacob CC, Antunes AMM*. High resolution mass spectrometry-based methodologies for identification of Etravirine bioactivation to reactive metabolites: In vitro and in vivo approaches. Eur J Pharm Sci. 2018 119, 70-82. http://doi.org/10.1016/j.ejps.2018.03.026.
11. Pinheiro PF, Pereira SA, Harjivan SG, Martins IL, Marinho AT, Cipriano M, Jacob CC, Oliveira NG, Castro MF, Marques MM, Antunes AMM*, Miranda JP*. Hepatocyte spheroids as a competent in vitro system for drug biotransformation studies: nevirapine as a bioactivation case study. Arch Toxicol 2017, 91, 1199-1211. http://doi.org/10.1007/s00204-016-1792-x
- Grilo NM, João Correia M, Miranda JP, Cipriano M, Serpa J, Marques MM, Monteiro EC, Antunes AMM, Diogo LN, Pereira SA. Unmasking efavirenz neurotoxicity: Time matters to the underlying mechanisms. Eur J Pharm Sci. 2017, 105, 47-54; http://doi.org/10.1016/j.ejps.2017.05.010.
- Morgado PI, José S, Wanke R, Antunes AMM, Cardoso AS, Jordão L. Integration of cellular and molecular endpoints to assess the toxicity of polycyclic aromatic hydrocarbons in HEPG2 cell line. Environ Toxicol Chem 2017, 36, 3404-341. http://doi.org/10.1002/etc.3927
14. Nunes J, Martins IL, Catarina Charneira C, Pogribny IP, de Conti A, Beland FA, Marques MM, Jacob CC, Antunes AMM*. New insights into the molecular mechanisms of chemical carcinogenesis: in vivo adduction of histone H2B by a reactive metabolite of the chemical carcinogen furan, Toxicol Lett 2016, 264,106-113. http://doi.org/10.1016/j.toxlet.2016.10.018
15. Grilo NM, Correia MJ, Sequeira C, Harjivan SG, Caixas U, Diogo LN, Marques MM, Monteiro EC, Antunes AMM, Pereira SA*. Efavirenz biotransformation as an up-stream event of mood changes in HIV-infected patients. Toxicol Lett 2016, 260, 28-35. http://doi.org/10.1016/j.toxlet.2016.08.009
16. Marinho AT, Dias CG, Pinheiro PF, Lemos AR, Antunes AMM, Marques MM, Monteiro EC, Miranda JP, Pereira SA*. Nevirapine modulation of paraoxonase-1 in the liver: An in vitro three-model approach. Eur J Pharm Sci. 2016, 82, 147-53. http://doi.org/10.1016/j.ejps.2015.11.019
17. Martins ICB, Sardo M, Santos SM, Fernandes A, Antunes AMM, André V, Mafra L, Duarte MT, Packing interactions and physicochemical properties of novel multicomponent crystal forms of the anti-inflammatory azelaic acid studied by X-ray and solid-state NMR, Cryst Growth Des 2016, 16, 154–166. http://doi.org/10.1021/acs.cgd.5b01057
18. Martins IL, Charneira C, Gandin V, Ferreira da Silva JL , Justino GC, Telo JP, Vieira AJSC, Marzano C, Antunes AMM*, Selenium-containing Chrysin and Quercetin Derivatives: Attractive scaffolds for cancer therapy. J Med Chem 2015, 58, 4250-4265. http://doi.org/10.1021/acs.jmedchem.5b00230
19. Harjivan SH, Pinheiro PF, Martins IL, Godinho AL, Wanke R, Santos PP, Pereira SA, Beland FA, Marques MM, Antunes AMM*, Quinoid derivatives of the nevirapine metabolites 2-hydroxy- and 3-hydroxy-nevirapine: activation pathway to amino acid adduct. Toxicol Res 2015, 4, 1565-1577. http://doi.org/10.3390/molecules17032616
20. Pinheiro PF, Marinho AT, Antunes AMM, Marques MM, Pereira SA*, Miranda JP*. Sex differences in hepatic and intestinal contributions to nevirapine biotransformation in rats. Chem Biol Interact 2015, 233, 115-121. http://dx.doi.org/10.1016/j.cbi.2015.03.024
21. Grilo NM, Charneira C, Pereira SA, Monteiro EC, Marques MM, Antunes AMM*, Bioactivation to an aldehyde metabolite – possible role in the onset of toxicity induced by the anti-HIV drug abacavir, Toxicol Lett 2014, 224, 416-423.; http://dx.doi.org/10.1016/j.toxlet.2013.10.036
22. Harjivan SH, Wanke R, Ferreira da Silva JL; Marques MM, Antunes AMM*, The phenolic metabolites of the anti-HIV drug efavirenz: evidence for distinct reactivities upon oxidation with Frémy's salt. Eur J Med Chem 2014, 74, 7–11. http://dx.doi.org/10.1016/j.ejmech.2013.12.022.
23. Dias CG, Batuca JR, Marinho AT, Caixas U, Monteiro EC, Antunes AMM, Pereira SA*, Quantification of the arylesterase activity of paraoxonase-1 in human blood. Anal Methods 2014, 6, 289-294. http://dx.doi.org/10.1039/C3AY41527A
24. Marinho AT, Godinho ALA, Novais DA, Antunes AMM, Marques MM, Ramos T, G. Dias CG, Emília C. Monteiro EC, Pereira SA, Development and validation of an HPLC-UV method for quantifying nevirapine and its main Phase I metabolites in human blood. Anal Methods 2014, 6, 1575-1580. http://dx.doi.org/10.1039/C3AY41911H
25. Marinho AT, Rodrigues PM, Caixas U, Antunes AMM, Branco T, Shrika GH, Marques MM, Monteiro EC, Pereira, SA*, Differences in nevirapine biotransformation as a factor for its sex-dependent dimorphic profile of adverse drug reactions, J Antimicrob Chemother 2014, 69, 476-482. http://dx.doi.org/10.1093/jac/dkt359.
26. Pinto M, Rebola M, Louro H, Antunes AMM, José SS, Rocha M, Silva MJ, Cardoso AS, Chlorinated Polycyclic Aromatic Hydrocarbons Associated with Drinking Water Disinfection: Synthesis, Formation under Aqueous Chlorination Conditions and Genotoxic Effects, Polycyclic Aromat Compd 2014, 34, 356-371. http://dx.doi.org/10.1080/10406638.2014.891143
27. Moneo A, Justino GC, Carvalho MF, Oliveira MC, Antunes AMM, Bléger D, Hecht S, Telo JP, Electronic Communication in Linear Oligo(azobenzene) Radical Anions. J Phys Chem A 2013, 117, 14056–14064. http://dx.doi.org/10.1021/jp407099c
28. Wanke R*, Harjivan SG, Pereira SA, Marques MM, Antunes AMM*, The role of competitive binding to human serum albumin on efavirenz-warfarin interaction: a nuclear magnetic resonance study, Int J Antimicrob Agents 2013, 42, 443-444. http://dx.doi.org/10.1016/j.ijantimicag.2013.06.023
29. Quaresma S, André V, Antunes AMM, Cunha-Silva L, Duarte MT, Gabapentin Coordination Networks: Mechanochemical Synthesis and Behavior under Shelf Conditions, Cryst Growth Des 2013, 13, 5007–5017. http://dx.doi.org/10.1021/cg401187x
30. Grilo NM, Antunes AMM*, Caixas U, Marinho AT, Charneira C, Oliveira MC, Marques MM, Pereira SA*, Monitoring abacavir bioactivation in humans: screening for an aldehyde metabolite. Toxicol Lett 2013 219, 59-64. http://dx.doi.org/10.1016/j.toxlet.2013.02.021
31. dos Santos EA, Hamel E, Bai R, Burnett J, Santos CC, Tozatti S, Bogo D, Perdomo RT, Antunes AMM, Marques MM, Matos MFC, de Lima DP, Synthesis and evaluation of diaryl sulfides and diaryl selenide compounds for antitubulin and cytotoxic activity. Bioorganic Med Chem Lett 2013 15. 23, 4669-4673. http://dx.doi.org/10.1016/j.bmcl.2013.06.009
32. Antunes AMM*, Wolf B, Oliveira MC, Beland FA, Marques MM*, 2'-Deoxythymidine Adducts from the Anti-HIV Drug Nevirapine. Molecules 2013,18, 4955-4971. http://dx.doi.org/0.3390/molecules18054955.
33. Martins IL, Miranda JP, Oliveira NG, Fernandes AS, Gonçalves S, Antunes AMM*, Synthesis and biological activity of 6-selenocaffeine: potential modulator of chemotherapeutic drugs in breast cancer cells. Molecules 2013, 18, 5251-5264.; http://dx.doi.org/10.3390/molecules18055251
34. Charneira C, Grilo NM, Pereira SA, Godinho ALA, Monteiro EC, Marques MM, Antunes AMM*. N-terminal valine adduct from the anti-HIV drug abacavir in rat hemoglobin as evidence for abacavir metabolism to a reactive aldehyde in vivo. Br J Pharmacol 2012, 167, 1353-1361. http://dx.doi.org/10.1111/j.1476-5381.2012.02079.x.
35. Caixas U, Antunes AMM*, Marinho AT, Godinho AL, Grilo NM, Marques MM, Oliveira MC, Branco T, Monteiro EC, Pereira SA*. Evidence for nevirapine bioactivation in man: searching for the first step in the mechanism of nevirapine toxicity. Toxicology 2012, 301, 33-39. http://dx.doi.org/10.1016/j.tox.2012.06.013.
36. Wanke R, Novais DA, Harjivan SG, Marques MM, Antunes AMM*, Biomimetic oxidation of aromatic xenobiotics: synthesis of the phenolic metabolites from the anti-HIV drug Efavirenz, Org Biomol Chem 2012, 10, 4554-4561. Classified as “Hot Paper” and highlighted at OBC blog (http://blogs.rsc.org/ob/2012/05/21/hot-biomimetic-oxidation-of-aromatic-xenobiotics-synthesis-of-the-phenolic-metabolites-from-the-anti-hiv-drug-efavirenz//). http://dx.doi.org/10.1039/c2ob25212k.
37. Antunes AMM*, Sidarus M, Novais DA, Harjivan SG, Santos PP, Ferreira da Silva, JL, Beland FA, Marques MM, Oxidation of 2-Hydroxynevirapine, a Phenolic Metabolite of the Anti-HIV Drug Nevirapine: Evidence for an Unusual Pyridine Ring Contraction, Molecules 2012, 17, 2616-2627. http://dx.doi.org/10.3390/molecules17032616
38. Charneira C, Godinho ALA, Oliveira MC, Pereira SA, Monteiro EC, Marques MM, Antunes AMM*, Reactive Aldehyde Metabolites from the Anti-HIV Drug Abacavir: Amino Acid Adducts as Possible Factors in Abacavir Toxicity, Chem Res Toxicol 2011, 24, 2129-2141. http://dx.doi.org/10.1021/tx200337b
39. Antunes AMM*, Novais DA, Ferreira da Silva JL, Santos PP, Oliveira MC, Beland FA, Marques MM, Synthesis and oxidation of 2-hydroxynevirapine, a metabolite of the HIV reverse transcriptase inhibitor nevirapine, Org Biomol Chem 2011, 9, 7822-7835. http://dx.doi.org/10.1039/c1ob06052j.
40. Antunes AMM*, Godinho ALA, Martins IL, Oliveira MC, Gomes RA, Coelho AV, Beland FA, Marques MM, Protein adducts as prospective biomarkers of nevirapine toxicity, Chem Res Toxicol 2010, 23 ,1714–1725 – Highlighted in "In This Issue" section of the CRT.; http://dx.doi.org/10.1021/tx100186t
41. Antunes AMM*, Godinho ALA, Martins IL, Justino GC, Beland FA, Marques MM, Amino acid adduct formation by the nevirapine metabolite, 12-hydroxynevirapine – a possible factor in nevirapine toxicity, Chem Res Toxicol 2010, 23, 888–899. http://dx.doi.org/10.1021/tx900443z
42. Santos PMP, Antunes AMM, Noronha J, Fernandes E, Vieira AJSC*, Scavenging Activity of Aminoantipyrines against Hydroxyl Radical, Eur J Med Chem 2010, 45, 2258–2264. http://dx.doi.org/10.1016/j.ejmech.2010.01.071
43. Antunes AMM*, Duarte MP, Santos PP, Gamboa da Costa G, Heinz TM, Beland FA, Marques MM, Synthesis and Characterization of DNA Adducts from the HIV Reverse Transcriptase Inhibitor Nevirapine, Chem Res Toxicol 2008, 21, 1443–1456.; http://dx.doi.org/10.1021/tx8000972
44. Brás AR, Noronha JP, Antunes AMM, Cardoso M., Schönhals A, Affouard F, Dionisio M, Correia NT, Molecular motions in Amorphous Ibuprofen as Studied by Broadband Dielectric Spectroscopy, J Phys Chem B 2008, 112, 11087–11099.; http://dx.doi.org/10.1021/jp8040428
45. Fonseca C, Neves AR, Antunes AMM, Noronha JP, Hahn-Hägerdal B, Santos H, Spencer-Martins I*, Use of In Vivo 13C Nuclear Magnetic Resonance Spectroscopy To Elucidate L-Arabinose Metabolism in Yeasts, Appl Environ Microbiol 2008, 74(6), 1845-1855. http://dx.doi.org/10.1128/AEM.02453-07
46. Antunes AMM, Bonifácio VDB, Nascimento SCC, Lobo AM, Branco PS, Prabhakar S*, Palladium(II) mediated aziridination of olefins with bromamine-T as the nitrogen source: scope and mechanism, Tetrahedron 2007, 63, 7009-7017. Highlighted in Chem Inform (http://onlinelibrary.wiley.com/doi/10.1002/chin.200744094/full). http://dx.doi.org/10.1016/j.tet.2007.05.020
47. Li L, Chiarelli MPl, Branco PS, Antunes AM, Marques MM, Gonçalves LL, Beland FA*, Differentiation of isomeric C8-substituted alkylaniline adducts of guanine by electrospray ionization and tandem quadropole ion trap mass spectrometry, J Am Soc Mass Spectrom 2003, 14, 1488-1492. http://dx.doi.org/10.1016/j.jasms.2003.08.009
48. Antunes AMM, Branco PS, Lobo AM, Prabhakar S*, Palladium (II)-promoted aziridination of olefins with bromoamine T as the nitrogen transfer agent, Chem Comm 2001, 405-406. Highlighted in Chem Inform (http://onlinelibrary.wiley.com/doi/10.1002/chin.200124116/abstract). http://dx.doi.org/10.1039/B008701G
49. Branco PS, Antunes AMM, Marques MM, Chiarelli MP, Lobo AM, Prabhakar S*, New syntheses of DNA adducts from methylated anilines present in tobacco smoke, Chem Res Toxicol 1999, 12, 1223-1233. http://dx.doi.org/10.1021/tx9901229
50. Chiarelli MP, Wu HP, Branco PS, Antunes AM, Product Ion Studies of Some Novel Arylamine Adducts of Deoxyguanosine by Matrix-assisted Laser Desorption/Ionization and Post-source Decay, Rapid Commun Mass Spectrom 1999, 13, 2004-2010. http://dx.doi.org/10.1002/(SICI)1097-0231(19991030)13:20<2004::AID-RCM745>3.0.CO;2-M
51. Chiarelli MP, Wu HP, Branco PS, Antunes AM, Post-Source decay product ion studies of anilines and methylated aniline adducts of deoxyguanosine, Anal Chim Acta 1999, 397, 257-265. http://dx.doi.org/10.1016/S0003-2670(99)00410-9
52. Antunes AM, Fonseca TF, Santos SMBP, Isonothoapiol: A New Phenylterpenoid from Ammi Huntii, Nat Prod Lett 1997, 11, 77-80 (currently Natural Product Research). Citations: 0
53. Antunes AM, Santos SP, Palma FMSB, Isomyrysticine: 1H and 13C-NMR assignments, Fitoterapia 1995, LXVI(6), 554.
*, corresponding author,