Sumários
Introduction to Systems Biology
18 abril 2013, 11:30 • Miguel Nobre Parreira Cacho Teixeira
Introduction to Systems Biology. Definition and goals of this new discipline. Mathematical modeling of biochemical and regulatory pathways: general concepts, constraints and assets. The FLR1 regulatory network as a Systems Biology case-study. Genomic Scale Models. Sctoichiometric matrix. Fluxome analysis.
Metabolomics data analysis
17 abril 2013, 12:30 • Miguel Nobre Parreira Cacho Teixeira
Metabolomics data analysis using the online tool MetaboAnalyst: statistical (Correlation analysis, PCA, PLS-DA and clustering) and pathway enrichment analysis. Biological interpretation of the data.
Metabolomics data analysis
16 abril 2013, 15:30 • Miguel Nobre Parreira Cacho Teixeira
Metabolomics data analysis using the online tool MetaboAnalyst: statistical (Correlation analysis, PCA, PLS-DA and clustering) and pathway enrichment analysis. Biological interpretation of the data.
Metabolomics analysis
16 abril 2013, 09:00 • Miguel Nobre Parreira Cacho Teixeira
Metabolomics: definition and principles. Critical analysis of sample preparation and metabolite extraction methods.Metabolomics analysis using MS approaches: GS-MS, LC-MS and DIMS. Metabolomics analysis based on NMR. Chemometrics approaches to NMR or MS data analysis: PCA and PLS-DA. Examples of application of metabolomics tools to the study of silent mutations, functional genomics and metabolic module definition.
Genome-wide data analysis using bioinformatics tools
12 abril 2013, 13:30 • Miguel Nobre Parreira Cacho Teixeira
Integrated transcriptome and disruptome data analysis using bioinformatics tools: GOToolBox, KEGG, YEASTRACT and STRING. The propionic acid case-study.