Sumários

.

3 novembro 2022, 14:00 Maria Matilde Soares Duarte Marques

Beta peptides. Peptidomimetics.

Chemical synthesis of oligonucleotides.
The priciple of m-RNA vaccines. Application to SARS-Cov2.


Glycosylation

27 outubro 2022, 14:00 Ana Cristina da Silva Fernandes

Structure and synthesis of O-glycosides, N-glycosides, S-glycosides and C-glycosides. Glycosidic bond. Examples of disaccharides, oligosaccharides, polysaccharides and glycoconjugates (glycoproteins and glycolipids). Cyclodextrins: structure and applications. Examples of methods for synthesizing oligosaccharides and polysaccharides.


Ribozymes, DNAzymes and Abzymes. Basic structures of nucleic acids.

27 outubro 2022, 09:00 Maria Matilde Soares Duarte Marques

Ribozymes - catalytic DNA and what it works. Artificial ribozymes.

DNAzymes (Catalytic DNA).
Abzymes  (monoclonal antibodies with catalytic activity) - production and uses.
Basic structures of nucleic acids. Therapeutic application of antimetabolite nucleoside analogues. Antisense therapy.


Metalloproteins

25 outubro 2022, 14:00 Maria Matilde Soares Duarte Marques

Metalloproteins: Storage and transport metalloproteins and metalloenzymes. Selected examples.


Introduction of carbohydrate chemistry.

20 outubro 2022, 14:00 Ana Cristina da Silva Fernandes

Introduction to carbohydrate chemistry. Classification of Monosaccharides. Aldoses and Ketoses. Stereochemistry of monosaccharides. Linear and cyclic structure of monosaccharides. Fisher, Haworth and Chair of carbohydrates. Mutarotation. Reducing sugars. Some examples of the reaction of monosaccharides: oxidation, reduction, isomerization, Kiliani-Fischer Synthesis, oxidative Cleavage, osazone synthesis and introduction of protecting groups.