Hydrogenation (aula online)

17 Dezembro 2020, 16:00 Luísa Margarida Martins

Enantioselective hydrogenation of alkenes. Wilkinson catalyst and mechanism. Selectivity. L-DOPA synthesis. Ligands and catalysts. Enamide hydrogenation. Enantioselective hydrogenation of ketones. Noyori catalysts and mechanisms. Industrial applications of asymmetric hydrogenations. Exercises.

Cross Coupling Reactions (aula online)

15 Dezembro 2020, 16:30 Luísa Margarida Martins

C-C cross coupling reactions. Catalytic cycles and industrial application examples of palladium catalyzed coupling reactions: Mizoroki- Heck, Suzuki-Miyaura, Kumada-Corriu, Negishi and Sonogashira. Henry nitroaldol C-C coupling. Palladium-catalyzed carbon-nitrogen bond formation. Hartwig-Buchwald. Decarboxylative C-C cross-coupling. Exercises.

Alcohol and ketone oxidation (aula online)

10 Dezembro 2020, 16:00 Luísa Margarida Martins

Baeyer-Villiger oxidation of ketones; peracid oxidants and Criegee's mechanism. Metal catalyzed Baeyer-Villiger oxidation of ketones. Mechanism and examples. Oxidation of cyclobutanones. Oxidation of other ketones. Baeyer-Villiger oxidation in water. Catalytic oxidations of primary and secondary alcohols. Cascade reactions to value-added products from alcohols. Aerobic and peroxidative catalytic oxidation of alcohols. Mechanism and examples. Oxidation of phenols. Catalyst design: chemoselectivity. Sustainable approaches for the oxidation of alcohols. Exercises.

Alkene oxidation (aula online)

3 Dezembro 2020, 16:00 Luísa Margarida Martins

Oxidation of olefins to carbonyl compounds (Wacker process). Reaction of ethylene with palladium compounds. Kinetics and mechanism. Technical applications: acetaldehyde from ethylene. Application of the olefin oxidation to organic syntheses.  Alkene epoxidation. Epoxide uses and markets. Production of propylene oxide. Production of ethylene oxide. Catalysts in homogeneous epoxidation reactions. Exercises.

Polymerization (aula online)

26 Novembro 2020, 16:00 Maria de Fátima Costa Guedes da Silva

Condensation polymerization and addition polymerization. Di-, oligo- and polymerization of alkenes. Cossee mechanism.

SHOP oligomerization of ethylene to alfa-olefines.

Tacticity of a polymer. 

Ziegler-Natta catalysts; mechanism. Metallocene catalysts; Kaminsky catalytic system.

Copolymerization of ethylene and CO.