Cross Coupling Reactions

11 novembro 2021, 10:30 • Luísa Margarida Martins

C-C cross coupling reactions. Catalytic cycles and industrial application examples of palladium catalyzed coupling reactions: Mizoroki- Heck, Suzuki-Miyaura, Kumada-Corriu, Negishi and Sonogashira. Henry nitroaldol C-C coupling. Palladium-catalyzed carbon-nitrogen bond formation. Hartwig-Buchwald. Exercises.

Exercises and Evaluation

10 novembro 2021, 14:00 • Luísa Margarida Martins

Evaluation: MAP3

Polymerization

8 novembro 2021, 11:00 • Maria de Fátima Costa Guedes da Silva

Condensation polymerization, addition polymerization and coordination polymerization. Di-, oligo- and polymerization of alkenes. Cossee mechanism.

SHOP oligomerization of ethylene to alfa-olefines.

Tacticity of a polymer. 

Ziegler-Natta catalysts; mechanism. Metallocene catalysts; Kaminsky catalytic system.

Copolymerization of ethylene and CO.

Oxidation

4 novembro 2021, 10:30 • Luísa Margarida Martins

Oxidation of Hydrocarbons. Oxidation of p-xylene and alkanes. Oxidation of olefins to carbonyl compounds (Wacker process). Alkene epoxidation. Epoxide uses and markets. Production of propylene oxide.  Catalysts in homogeneous epoxidation reactions. Baeyer-Villiger oxidation of ketones; peracid oxidants and Criegee's mechanism. Metal catalyzed Baeyer-Villiger oxidation of ketones. Mechanism and examples. Baeyer-Villiger oxidation in water. Catalytic oxidations of primary and secondary alcohols. Cascade reactions to value-added products from alcohols. Aerobic and peroxidative catalytic oxidation of alcohols. Mechanism and examples. Oxidation of phenols. Catalyst design: chemoselectivity. Sustainable approaches for the oxidation of alcohols. Exercises.

Hydroformylation

3 novembro 2021, 14:00 • Luísa Margarida Martins

Hydroformylation of olefins. Catalytic systems. Cobalt vs. rhodium catalysts: catalytic cycles. Cobalt- based processes. Rhodium-based processes. Regioselectivity and chemoselectivity. Ligands effects. Low Pressure OxoSM Process. Ruhchemie/Rhône-Poulen process. Economic and environmental aspects. Assymetric hydroformylation. Exercises.