21 Março 2017, 10:38 - Ana Maria de Almeida Nogueira Marques
Title: Large-scale data analysis for the characterization of human gene expression patterns across hundreds of individuals and dozens of tissues
Speaker: Pedro Gabriel Dias Ferreira, Ipatimup/i3s
Date and time: Monday, March 27, 15:00 pm
Location: CSE meeting room (Informática II - Alameda), videocast to DSI room in Tagus.
The emergence of high-throughput sequencing has brought substantial advances in human population and cancer genomics research. Such advances made possible to assay with high depth of coverage the DNA and RNA of tumor and normal samples creating an unprecedented explosion of data. Several large-scale consortia, such as TCGA, ICGC, ENCODE, GEUVADIS or GTEx are dedicated to the comprehensive sequencing, characterization and analysis of the genomic changes in different types of tumors, cell lines or tissues. While these datasets bring new opportunities in extending our biological knowledge they also bring new challenges on the computational aspects of data analysis. In this talk, I will describe some of our recent results in the characterization of the transcriptional patterns across dozens of tissues and hundreds of individuals within the scope of GTEx and other large scale sequencing projects. The applied methodology used for data analysis will be explained. The relevance of these findings for biomedical research and future perspectives will also be discussed.
Pedro G. Ferreira graduated in Systems and Informatics Engineering in 2002 and completed his PhD in Artificial Intelligence from the University of Minho in November 2007 with a scholarship from FCT-Portugal. From 2008 to 2012, he was a Postdoctoral Fellow at the Bioinformatics and Genomics Laboratory, Center for Genomic Regulation (CRG), Barcelona. He was supported by an FCT-Portugal fellowship in the first 3 years. During this period he worked extensively with next generation sequencing (NGS) data. He collaborated with several groups in the CRG and the University Pompeu Fabra and several international consortia. In November 2012, he joined as a Postdoctoral Fellow the Functional Population Genomics and Genetics of Complex Traits group, School of Medicine, University of Geneva. His research was focused on genomics for personalized health. During his two postdocs, he was or is involved in four major international consortia: ENCODE, ICGC-CLL, GEUVADIS and GTEx. In August 2014, he joined the start-up company Coimbra Genomics as a senior bioinformatics specialist. He worked in the design and development of clinical decision support systems for personalized medicine. Late 2014, he was awarded an FCT Investigator ‘Starting grant’ and in May 2015 he started at IPATIMUP. His main research focus is the development of information systems to interpret personal genomics data for clinical diagnosis and precision medicine.
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16 Novembro 2016, 10:33 - Ana Maria de Almeida Nogueira Marques
Candidata: Leila Sharifi Nº 77284/D
Título: “Energy-aware Service Provisioning in P2P-assisted Cloud
Data: 23 de novembro de 2016
Local: Anfiteatro PA-3 (Piso -1, Pavilhão de Matemática) do IST - Alameda
Orientação: Professor Luís Manuel Antunes Veiga
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