Dissertações
2025/2026
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Mechanosynthesis of advanced polyurea dendrimers for chemotherapeutics DRAFT
Author: André Ricardo de Almeida Vieira Monteiro (ist1113223)
Coordenação: Vasco Daniel Bigas Bonifácio (ist90152)
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Mechanosynthesis of selenium chitins and chitosans for regenerative medicine and therapeutics DRAFT
Author: Andreia de Deus Fialho (ist1112302)
Coordenação: Vasco Daniel Bigas Bonifácio (ist90152)
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Migration-based mechanisms of arteriogenesis DRAFT
Author: Maria Luísa Horta e Costa Ferrugento Gonçalves (ist1100431)
Coordenação: Simão José Teixeira da Rocha (ist428900)
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Targeting Glucagon Signaling and Cysteine Metabolism in Hepatocellular Carcinoma (HCC): A Novel Therapeutic Strategy DRAFT
Author: Santiago de Milne e Carmo Ramalho (ist1112353)
Coordenação: Vasco Daniel Bigas Bonifácio (ist90152)
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Bottom-up reconstruction of a synthetic erythrocyte: membrane properties, biomechanical assessment and cell-cell interactions DRAFT
Author: Carolina Lourenço Silvestre Pereira Calado (ist1100383)
Coordenação: Cláudia Alexandra Martins Lobato da Silva (ist31519)
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Targeted Delivery of Extracellular Vesicles to Metastatic Breast Cancer Cells Using the Tumor-Targeting Peptide p28 DRAFT
Author: Maria Madalena Mendes da Costa Cruz e Silva (ist199624)
Coordenação: Cláudia Alexandra Martins Lobato da Silva (ist31519) Nuno Filipe Santos Bernardes (ist153406)
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Dual-Imaging Radiocomplexes for Prostate Cancer DRAFT
Author: Joana José Arraia (ist1112101)
Coordenação: Célia Maria Da Cruz Fernandes (ist25452)
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Microfluidic cell-chips for an in vitro hepatic disease model DRAFT
Author: Sara Costalonga (ist1112389)
Coordenação: João Pedro Estrela Rodrigues Conde (ist12146)
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Development of a cyclic olefin copolymer (COC) based organ-on-a-chip (OOC) device with integrated sensing for continuous monitoring of the cell culture DRAFT
Author: Elisa Simioni (ist1112370)
Coordenação: Arsénio do Carmo Sales Mendes Fialho (ist12833)
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Development of Metrology Methods for Microfluidic Devices including Organ-on-Chip DRAFT
Author: Ricardo da Glória Amado (ist1112318)
Coordenação: Vânia Cristina Henriques Silvério (ist32734)
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Strategies for iPSC Differentiation into Endothelial Cells: A Literature and Transcriptomic Analysis of 2D and 3D Approaches Toward Organoid Vascularization DRAFT
Author: Mafalda Costa (ist198868)
Coordenação: Tiago Paulo Gonçalves Pinheiro Fernandes (ist147740)
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Ins and Outs of immunes cells in intestinal lymphatic vessels DRAFT
Author: Matilde dos Santos Nunes Loureiro Esteves (ist1112257)
Coordenação: Nuno Filipe Santos Bernardes (ist153406)
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Development of an Organ-on-chip (OOC) platform with integrated sensors based on the Coulter principle for monitoring of Hematopoietic stem/progenitor cells (HSPC) cultures DRAFT
Author: Beatriz Picanço Martins (ist1112303)
Coordenação: Cláudia Alexandra Martins Lobato da Silva (ist31519)
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Study of drug delivery to ocular cells using cell chips DRAFT
Author: Mafalda Montes Guerreiro (ist1112096)
Coordenação: João Pedro Estrela Rodrigues Conde (ist12146)
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Exploring the membrane interaction of disease-associated mutants of Tau protein: insights into Tauopathies and Alzheimer´s disease DRAFT
Author: Rúben Filipe Carvalho Matias (ist1112313)
Coordenação: Ana Margarida Nunes da Mata Pires de Azevedo (ist30470) Ana Margarida Pereira de Melo (ist90309)
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Functional Assessment of Anti-Fibrotic Nanoparticles in 2D and 3D Cardiac Models Derived from Human Pluripotent Stem Cells (hiPSCs) DRAFT
Author: Rebecca Dutton Tavares Rocha (ist1112097)
Coordenação: Tiago Paulo Gonçalves Pinheiro Fernandes (ist147740)
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Advanced polyurethane membranes for extracorporeal membrane oxygenation DRAFT
Author: Gabriela Valente Simões Finisterra Pereira (ist1113361)
Coordenação: Rita Figueiredo Pires (ist426705) Vasco Daniel Bigas Bonifácio (ist90152)
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Mechanosynthesis of Terpene Oligosulfides and Nanogold for Anticancer Therapy EVALUATED
Author: Jorge Miguel de Melo Gomes (ist138143)
Coordenação: Vasco Daniel Bigas Bonifácio (ist90152)
2024/2025
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Effect of physical exercise in the Cuprizone mouse model of demyelination EVALUATED
Author: Miguel Leonardo Pereira Marques Mendes Grilo (ist192529)
Coordenação: Tiago Paulo Gonçalves Pinheiro Fernandes (ist147740)
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High-fat diet and the brain’s repair system: miR-21 as a molecular link EVALUATED
Author: Sara Filipa Costa Rama (ist196092)
Coordenação: Tiago Paulo Gonçalves Pinheiro Fernandes (ist147740)
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3D tumor spheroid models to assess the biocompatibility and anticancer properties of p28-functionalized nanomedicines DRAFT
Author: Mafalda Costa (ist198868)
Coordenação: Arsénio do Carmo Sales Mendes Fialho (ist12833) Nuno Filipe Santos Bernardes (ist153406)
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Assaying Dry Powder Formulation Permeability Using Nasal Mucosa Air-Liquid Interface with RPMI 2650 cells EVALUATED
Author: Rita Martins Alexandre (ist429266)
Coordenação: Tiago Paulo Gonçalves Pinheiro Fernandes (ist147740)
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FISHing TERRA and Telomere Dynamics in the Zebrafish Spinal Cord: A Bioimaging Approach EVALUATED
Author: Ricardo Simões Ferreira Neto (ist199710)
Coordenação: Tiago Paulo Gonçalves Pinheiro Fernandes (ist147740)
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Impact of the hematopoietic niche on leukemia cell survival in vitro EVALUATED
Author: Mariana de Figueiredo Machado (ist196622)
Coordenação: Ana Margarida Pires Fernandes Platzgummer (ist46782) Cláudia Alexandra Martins Lobato da Silva (ist31519)
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Long-term Characterization of the K/BxN Mouse Model of Arthritis and Evaluation of JAK Inhibitors in Disease Control EVALUATED
Author: Maria António Gaspar (ist1108294)
Coordenação: Maria Margarida Fonseca Rodrigues Diogo (ist24804)
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High-Throughput personalized drug screening for multiple Myeloma using a 3D ex vivo model EVALUATED
Author: Maria Margarida Maia Domingos (ist1108306)
Coordenação: Cláudia Alexandra Martins Lobato da Silva (ist31519)
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Decoupling the Isoform-Specific Impact of Genomic and Transcriptional Variations in the Dual Coding CDKN2A Gene in Cancer EVALUATED
Author: Maria Duarte Ferreira Guerra (ist198856)
Coordenação: Emanuel José Vieira Gonçalves (ist429071)
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Uncovering the Transcriptional Network that protects macrophages from Ferroptosis EVALUATED
Author: Martim Betencourt Tavares Milheiro da Costa (ist1100436)
Coordenação: Tiago Paulo Gonçalves Pinheiro Fernandes (ist147740)
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Towards a markerless deletion mutant protocol in an Alicyclobacillus genus background: the case of removing the flagellum-based motility function EVALUATED
Author: Carlos Frederico Furtado Vilar (ist1107389)
Coordenação: Nuno Gonçalo Pereira Mira (ist148703)
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Development of a scalable bioprocess for the generation of hiPSC-derived kidney progenitor cells for organoid production EVALUATED
Author: Mariana Coelho dos Santos (ist195897)
Coordenação: Ana Margarida Pires Fernandes Platzgummer (ist46782)
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Mapping plasma cell neoplasms electronics towards nanotherapeutics DRAFT
Author: Jorge Miguel de Melo Gomes (ist138143)
Coordenação: Vasco Daniel Bigas Bonifácio (ist90152)
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T-MoMa: Therapeutical Molecular Materials Exploration of the potential cytotoxic activity of nBu4N [M(dcbdt)2]z- salts EVALUATED
Author: Sara Fava Gonçalves (ist199877)
Coordenação: Sandra Marisa Baptista Rabaça Rodrigues (ist171735) Maria Dulce Jesus Pombo Belo (ist171949)
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Functionalised PEDOT nanoparticles as a bioelectronic platform for drug delivery and imaging EVALUATED
Author: Danaja Lorenčič (ist1108412)
Coordenação: Paola Sanjuan Alberte (ist428762) Teresa Sofia Araújo Esteves (ist32441)
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Engineering a immune-competent 3D hipsc-based cell model to study liver inflammation EVALUATED
Author: Maria França da Graça Fonseca Pereira (ist196616)
Coordenação: Tiago Paulo Gonçalves Pinheiro Fernandes (ist147740)
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Optimization of tumor spheroid production of colo-rectal cancer cell lines in 3D culture systems EVALUATED
Author: João Henrique Martins Roque Botelho (ist1111013)
Coordenação: Ana Margarida Pires Fernandes Platzgummer (ist46782) Nuno Filipe Santos Bernardes (ist153406)
2023/2024
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Formulation and characterization of bioinks towards 3D bioprinting of a liver lobule based on human induced pluripotent stem cells EVALUATED
Author: Paola Joaquina de Gouveia Pirela (ist1102257)
Coordenação: Tiago Paulo Gonçalves Pinheiro Fernandes (ist147740) Paola Sanjuan Alberte (ist428762)
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Unravelling how melanoma extracellular vesicles establish pre-metastatic niches in the lungs EVALUATED
Author: Maria João Teixeira da Costa de Almeida (ist196618)
Coordenação: Ana Margarida Pires Fernandes Platzgummer (ist46782)
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Polygenic Risk Scores in Type 2 Diabetes: Analyzing Consensus and Clinical Viability EVALUATED
Author: Matilde Maria Pereira Henriques Pedro Lopes (ist192773)
Coordenação: Ana Teresa Correia de Freitas (ist13136)
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Bridging the immune and the endocrine systems to improve immunity DRAFT
Author: Maria Inês Queirós Miranda Ferreira das Neves (ist190414)
Coordenação: Cláudia Alexandra Martins Lobato da Silva (ist31519)
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Generation of 3D Hepatic Microtissues using Liver Organoids and 3D Bioprinting DRAFT
Author: Mafalda Arnaud Farinha Faria de Oliveira (ist195888)
Coordenação: Paola Sanjuan Alberte (ist428762) Tiago Paulo Gonçalves Pinheiro Fernandes (ist147740)
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Exploring Egg White-Alginate Bioink Formulations for Vascularized Neural Tissue Fabrication via 3D Bioprinting EVALUATED
Author: Raquel Ramos Pina (ist195904)
Coordenação: Tiago Paulo Gonçalves Pinheiro Fernandes (ist147740) Paola Sanjuan Alberte (ist428762)
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Assembly of Vascularized Neural Tissue using Organoids and 3D Bioprinting DRAFT
Author: Raquel Ramos Pina (ist195904)
Coordenação: Tiago Paulo Gonçalves Pinheiro Fernandes (ist147740) Paola Sanjuan Alberte (ist428762)
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In vivo dissection and validation of common molecular pathways affected in pre- symptomatic Drosophila models for ALS and SMA DRAFT
Author: Beatriz Reis de Carvalho (ist1102333)
Coordenação: Maria Margarida Fonseca Rodrigues Diogo (ist24804)
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In vivo dissection and validation of common molecular pathways affected in pre- symptomatic Drosophila models for ALS and SMA DRAFT
Author: Beatriz Reis de Carvalho (ist1102333)
Coordenação: Maria Margarida Fonseca Rodrigues Diogo (ist24804)
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Study of bacterial proteins that repair intracellular damage EVALUATED
Author: Ana Filipa Alves Rodrigues (ist1105782)
Coordenação: Miguel Nobre Parreira Cacho Teixeira (ist141827)
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Study of bacterial proteins that repair intracellular damage DRAFT
Author: Ana Filipa Alves Rodrigues (ist1105782)
Coordenação: Miguel Nobre Parreira Cacho Teixeira (ist141827)
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Development of a physiological 3D vascular wall model in vitro for future atherosclerosis research EVALUATED
Author: Carolina Maria Borrego Miguel (ist1106759)
Coordenação: Maria Margarida Fonseca Rodrigues Diogo (ist24804)
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Unraveling how melanoma extracellular vesicles (EVs) establish pre-metastatic niches in the lungs DRAFT
Author: Maria João Teixeira da Costa de Almeida (ist196618)
Coordenação: Ana Margarida Pires Fernandes Platzgummer (ist46782)
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Cell-derived nanovesicles: From characterization to biological applications EVALUATED
Author: Beatriz Sofia Mineiro de Avó (ist195863)
Coordenação: Fábio Monteiro Fernandes (ist45779) Sandra Cristina Nunes Trigo Fernandes Pinto (ist32860)
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Analysis of extracellular vesicle heterogeneity: Biophysical differences between subpopulations and their therapeutical potential DRAFT
Author: Beatriz Sofia Mineiro de Avó (ist195863)
Coordenação: Fábio Monteiro Fernandes (ist45779) Sandra Cristina Nunes Trigo Fernandes Pinto (ist32860)
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Formulation and Optimization of Bioinks for 3D Bioprinting of Vascularized Liver Tissues Using Human iPSCs EVALUATED
Author: Mafalda Arnaud Farinha Faria de Oliveira (ist195888)
Coordenação: Paola Sanjuan Alberte (ist428762) Tiago Paulo Gonçalves Pinheiro Fernandes (ist147740)
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Disclosing the cellular and molecular effects of low doses of ionizing radiation in dermal spheroids EVALUATED
Author: Carolina Aguiar Fernandes (ist195864)
Coordenação: Ana Margarida Pires Fernandes Platzgummer (ist46782)
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Disclosing the cellular and molecular effects of low doses of ionizing radiation in dermal spheroids and their synergistic contribution to regeneration DRAFT
Author: Carolina Aguiar Fernandes (ist195864)
Coordenação: Ana Margarida Pires Fernandes Platzgummer (ist46782)
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Assaying Dry Powder Formulation Permeability Using Nasal Mucosa Air-Liquid Interface with RPMI 2650 cells APPROVED
Author: Rita Martins Alexandre (ist429266)
Coordenação: Tiago Paulo Gonçalves Pinheiro Fernandes (ist147740)
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Nasal mucosa air-liquid interface (ALI) to predict the clinical permeability of nasally inhaled products DRAFT
Author: Rita Martins Alexandre (ist429266)
Coordenação: Tiago Paulo Gonçalves Pinheiro Fernandes (ist147740)
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The Neuroprotective Effect of Physical Exercise in the Cuprizone Mouse Model of Multiple Sclerosis APPROVED
Author: Miguel Leonardo Pereira Marques Mendes Grilo (ist192529)
Coordenação: Tiago Paulo Gonçalves Pinheiro Fernandes (ist147740)
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Effect of physical exercise in the Cuprizone mouse model of demyelination: a role for neural stem cells in remyelination DRAFT
Author: Miguel Leonardo Pereira Marques Mendes Grilo (ist192529)
Coordenação: Tiago Paulo Gonçalves Pinheiro Fernandes (ist147740)
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Transparent Insights for Medical Data: Enhancing Post-Surgical Consumable Recommendations with Explainable AI EVALUATED
Author: Ana Filipa Azinhais Figueiras (ist192655)
Coordenação: Daniel Pedro de Jesus Faria (ist147707)
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Transparent Insights for Medical Data: Integrating Explainable AI into Model Deployment Workflow DRAFT
Author: Ana Filipa Azinhais Figueiras (ist192655)
Coordenação: Daniel Pedro de Jesus Faria (ist147707)
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The crosstalk between hepatocytes and Kupffer cells in the liver - role in insulin resistance progression EVALUATED
Author: Raquel Inês Bozzo Carvalho (ist1105812)
Coordenação: Tiago Paulo Gonçalves Pinheiro Fernandes (ist147740)
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The crosstalk between hepatocytes and Kupffer cells in the liver - Role in insulin resistance progression DRAFT
Author: Raquel Inês Bozzo Carvalho (ist1105812)
Coordenação: Tiago Paulo Gonçalves Pinheiro Fernandes (ist147740)
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Modulation of hematopoietic stem and progenitor cell expansion in co-culture systems: Optimizing the protocol for feeder layer establishment EVALUATED
Author: Ana Rita Vicente Liça (ist1105719)
Coordenação: Cláudia Alexandra Martins Lobato da Silva (ist31519) Ana Margarida Pires Fernandes Platzgummer (ist46782)
2022/2023
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Preclinical Evaluation of Novel Antitumor Therapies in 3D Cell Models of Breast Cancer EVALUATED
Author: Diogo Miguel Gonçalves Engrácia (ist1102162)
Coordenação: Filipa Fernandes Mendes (ist25493)
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Biobanking and in vitro characterization of human salivary regeneration EVALUATED
Author: Ana Rita Fernandes Varela (ist1102292)
Coordenação: Cláudia Alexandra Martins Lobato da Silva (ist31519)
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Modelling Axonal Degeneration for FUS-ALS EVALUATED
Author: Sara Alice Da Conceição Cunha Cotrim Sebastião (ist191015)
Coordenação: Tiago Paulo Gonçalves Pinheiro Fernandes (ist147740)
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Establishing a Microfluidic System for High Throughput Encapsulation of Mesenchymal Stem Cells EVALUATED
Author: Marta Saraiva Campos Serra (ist192772)
Coordenação: Cláudia Alexandra Martins Lobato da Silva (ist31519)
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Engineering the Formation of Vascular Networks in Human Brain Organoids EVALUATED
Author: Ricardo Jorge Sousa Amaral (ist189778)
Coordenação: Tiago Paulo Gonçalves Pinheiro Fernandes (ist147740) Cláudia Daniela Canelas Miranda (ist166805)
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Engineering the Formation of Vascular Networks in Human Brain Organoids DRAFT
Author: Ricardo Jorge Sousa Amaral (ist189778)
Coordenação: Tiago Paulo Gonçalves Pinheiro Fernandes (ist147740) Cláudia Daniela Canelas Miranda (ist166805)
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ALS disrupts axon regeneration and promotes degeneration by altering axonal RNP granules DRAFT
Author: Sara Alice Da Conceição Cunha Cotrim Sebastião (ist191015)
Coordenação: Tiago Paulo Gonçalves Pinheiro Fernandes (ist147740)
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In vitro characterization of human salivary regeneration DRAFT
Author: Ana Rita Fernandes Varela (ist1102292)
Coordenação: Cláudia Alexandra Martins Lobato da Silva (ist31519)
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Avaliação pré-clínica de novas terapias anti-tumorais em modelos celulares 3D de cancro da mama DRAFT
Author: Diogo Miguel Gonçalves Engrácia (ist1102162)
Coordenação: Filipa Fernandes Mendes (ist25493)
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Development of Stem Cell-Derived Islets as a Regenerative Cell Replacement Therapy for Type 1 Diabetes. Pancreatic Polypeptide cells: A missing component in stem cell-derived islets EVALUATED
Author: Ana Matilde Matias Silvano (ist1102166)
Coordenação: Tiago Paulo Gonçalves Pinheiro Fernandes (ist147740)
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Generation of 3D Hepatic Microtissues using Liver Organoids and Additive Manufacturing DRAFT
Author: Paola Joaquina de Gouveia Pirela (ist1102257)
Coordenação: Tiago Paulo Gonçalves Pinheiro Fernandes (ist147740) Paola Sanjuan Alberte (ist428762)
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Generation of 3D Hepatic Microtissues using Liver Organoids and Additive Manufacturing DRAFT
Author: Paola Joaquina de Gouveia Pirela (ist1102257)
Coordenação: Tiago Paulo Gonçalves Pinheiro Fernandes (ist147740) Paola Sanjuan Alberte (ist428762)